| 第 37 卷第 5 期 |  | Vol. 37 No. 5 | | 2007 年 10 月 | Oct 2007 |
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所屬欄目：醫藥及中間體
催化加氫制備萘丁美酮工藝研究 |
| 李巍巍1，2，童國通1，呂路平1
（1.杭州職業(yè)技術(shù)學(xué)院 化工系，浙江 杭州 310018；2.浙江工業(yè)大學(xué) 化學(xué)工程與材料學(xué)院，浙江 杭州 310014） |
| 摘 要：選取催化劑、溶劑、脫水劑、溫度、壓力和反應時(shí)間作為重點(diǎn)考察的因素，進(jìn)行系列的單因素試驗和正交試驗，確定了4-（6-甲氧基-2-萘基）-1，3-丁二酮催化加氫制備萘丁美酮的優(yōu)化反應條件。以四氫呋喃為溶劑，催化劑Pd／C（10%）用量10%，對甲苯磺酸用量2%，氫氣壓力0.4 MPa，40℃下反應4 h，產(chǎn)品收率達88.3%，純度99.1%。 |
| 關(guān)鍵詞：萘丁美酮；催化加氫；正交試驗 |
| 中圖分類(lèi)號：R977.1 文獻標識碼：A 文章編號：1009-9212（2007）05- 0037-03 |
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| Preparation of Nabumetone by Catalytic Hydrogenation |
| LI Wei-wei1，2，TONG Guo-tong1，L?譈 Lu-ping1
（1. Chemical Department，Hangzhou Vocational and Technical College，Hangzhou 310018，China；2. College of Chemical Engineering and Material Science，Zhejiang University of Technology，Hangzhou 310014，China） |
| Abstract：Nabumetone was prepared from 4-（6-methoxy-2-naphthyl）-1，3- butandione by catalytic hydrogenation. Main interacting factors such as catalyst，solvent，dehydrating agent，temperature，pressure and reaction time were studied. The optimum conditions were as follows：40℃，0.4 MPa，Pd／C（10%）as catalyst，THF as solvent，2% p-toluene sulfonic acid as dehydrating agent and reaction time 4 hours. Under above conditions，the yield of nabumetone was up to 88.3% with the purity of 99.1% after recrystallization. |
| Key words：nabumetone；catalytic hydrogenation；orthogonal design |
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作者簡(jiǎn)介：李巍�。�1980-），男，湖北孝感人，助教，碩士研究生，研究方向：精細有機中間體合成。（E-mail：zgdlwwwwl@163.com）
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收稿日期：2007-06-05
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