| 第 38 卷第 3 期 |  | Vol. 38 No. 3 | | 2008 年 6 月 | Jun 2008 |
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所屬欄目：醫藥及中間體
L-高絲氨酸內酯鹽酸鹽的合成研究 |
| 滕漢兵
（武漢理工大學(xué) 化學(xué)工程學(xué)院，湖北 武漢 430070） |
| 摘 要：從L-蛋氨酸出發(fā)，分別采用“一鍋法”和兩步法探討了L-高絲氨酸內酯鹽酸鹽的合成。這兩種方法對常用的三步法進(jìn)行了改進(jìn)，簡(jiǎn)化了合成過(guò)程，減少了碘甲烷的用量，縮短了反應時(shí)間，提高了收率。兩步法雖增加了一次分離過(guò)程，但卻大大簡(jiǎn)化了最終產(chǎn)品的純化過(guò)程，有效避免了產(chǎn)品中無(wú)機鹽的引入，總收率可達到73.4％。 |
| 關(guān)鍵詞：氨基酸；L-高絲氨酸內酯鹽酸鹽；合成 |
| 中圖分類(lèi)號：O629.71 文獻標識碼：A 文章編號：1009-9212（2008）03- 0020-02 |
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| Study on Synthesis of L-Homoserine Lactone Hydrochloride |
| TENG Han-bing
（School of Chemical Engineering，Wuhan University of Technology，Wuhan 430070，China） |
| Abstract：The L-homoserine lactone hydrochloride was synthesized from L-methionine using both one-pot method and two-step method. The two methods were more efficient and convenient compared with the traditional three-step method. The synthetic process was simplified. Both the amount of CH3I and the reaction time were reduced greatly and the yield was increased. The results indicated that comparing with the one-pot, the two-step method simplified the purification of the target product greatly by increasing one separation step and effectively avoided the introduction of inorganic salt .The yield of the product reached 73.4%. |
| Key words：amino acid；L-homoserine lactone hydrochloride；synthesis |
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作者簡(jiǎn)介：滕漢兵（1977-），男，湖北武漢人，講師，博士，研究方向：非天然氨基酸的合成研究。（E-mail：wdthb@163.com）
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收稿日期： 2008-04-2
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