| 第 38 卷第 3 期 |  | Vol. 38 No. 3 | | 2008 年 6 月 | Jun 2008 |
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所屬欄目：香精香料
L-乳酸薄荷酯的合成 |
| 童志杰，鄭正春
（湖南醫藥工業(yè)研究所 湖南 長(cháng)沙 410014） |
| 摘 要：以薄荷醇和L-乳酸為原料，用環(huán)已烷帶水、經(jīng)酯化、精制得到L-乳酸薄荷酯，并研究了反應時(shí)間、醇酸摩爾比、催化劑量對反應的影響，確定的優(yōu)惠工藝條件為：n（薄荷醇） ∶ n（L-乳酸）=1.2 ∶ 1.0，催化劑為原料總重量2%，環(huán)己烷加熱回流帶水，反應6 h，減壓蒸餾至120℃／400 Pa。殘余物重結晶，得白色針狀結晶產(chǎn)品，收率80%以上，純度達到99%。 |
| 關(guān)鍵詞：薄荷醇；乳酸薄荷酯；合成 |
| 中圖分類(lèi)號：TQ655 文獻標識碼：A 文章編號：1009-9212（2008）03- 0045-02 |
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| Synthesis of Menthol Loctate |
| TONG Zhi-jie，ZHENG Zheng-chun
（Hunan Institute of Pharmaceutical Industry ，Changsha 410014，China） |
| Abstract：L-Lactic acid peppermint ester was synthesized from menthol and L-lactic acid through esterification in the presence of the cyclohexane including water. And meanwhile factors such as the reaction time，the alcoholacid mole and the catalyst dosage influencing the reaction were investigated, the optimal conditions were obtained as follow: 1.2 ∶ 1.0 of menthol and lactic acid，catalysts 2%（m／m），cyclohexane heat and reflow including water for 6 h，the reduced pressure distillation to 120℃／400 Pa. The residue was recrystallized to the white acicular crystalproduct. The yield and purity was above 80% and 99%，respectively. |
| Key words：menthol；menthol lactate；synthesis |
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作者簡(jiǎn)介：童志杰（1963-），男，湖南長(cháng)沙人，助理研究員。研究方向：有機合成及應用。
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收稿日期：2008-04-14
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