| 第 31 卷第 5 期 |  | Vol. 31 No. 5 | | 2001 年 10 月 | Oct 2001 |
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所屬欄目：其它
TiO_2/SO_4~(2-)型固體酸催化合成丙酮縮二甲醇 |
| 楊淑敏; 王海民; 呂劍; 劉鴻(西安近代化學(xué)研究所醫藥開(kāi)發(fā)部; 陜西西安) |
| 摘 要：原甲酸三甲酯和丙酮在TiO2 /SO4 2 - 型固體酸的催化作用下合成了丙酮縮二甲醇 ,并對諸影響因素進(jìn)行了考察。在反應溫度 0～ 5℃ ,反應時(shí)間 1h ,原料配比原甲酸三甲酯∶丙酮∶催化劑 (m /m) =10 6∶5 8∶4的優(yōu)惠工藝條件下 ,此反應可定量完成 ,精餾分離后收率94 .2 % ,純度 98.1%。催化劑可重復使用多次。用紅外、核磁驗證了產(chǎn)物結構 |
| 關(guān)鍵詞：丙酮縮二甲醇; TiO2/SO42-固體酸; 合成 |
| 中圖分類(lèi)號：TQ224.4 文獻標識碼：A 文章編號：1009-9212(2001)05-0026-02 |
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| Catalytic Synthesis of Acetone Dimehtyl Ketal with TiO_2/SO_4~(2-) Solid Acid |
| YANG Shu min; WANG Hai min; LU Jian; LIU Hong （Xi'an Modern Chemistry Research Institute the department of medical development; Shanxi Xi'an 710065） |
| Abstract：Acetone dimethyl acetal was synthesized from trimethyl orthoformate and acetone, the reaction was characterized by the catalysis of TiO 2/SO 4 2- solid acid and quantitative conversion. The influence factors were investigated, the results showed that the optimum conditions were as follows: reaction temperature 0～5℃, reaction time 1h, m(trimethyl orthoformate)∶m(acetone)∶m(solid acid)=106∶58∶4. The solid acid can be used repeatedly. The yield was 94.2% after rectification and the purity was 98.1%.... |
| Key words：acetone dimethyl acetal; TiO 2/SO 4 2- solid acid; synthesis |
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收稿日期：2001-04-17
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