| 第 41 卷第 3 期 |  | Vol. 41 No. 3 | | 2011 年 6 月 | Jun 2011 |
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所屬欄目：醫藥及中間體
磷酸苯二鈉的合成 |
| 李艷云，尹振晏*
（北京石油化工學(xué)院 化學(xué)工程學(xué)院，北京102617） |
| 摘 要：以苯酚、三氯氧磷和氫氧化鈉為原料合成了磷酸苯二鈉。研究了影響磷�；�、水解及中和反應的因素，優(yōu)化了反應條件，總收率可達69.2%。磷�；磻膬�(yōu)化條件為：物料配比ｎ（苯酚）∶ｎ（三氯氧磷）=1.0∶1.1，反應溫度130~140℃，反應時(shí)間10 h。經(jīng)減壓蒸餾、水解、中和得目標產(chǎn)品，收率90%。目標產(chǎn)品經(jīng)熔點(diǎn)測定、元素分析和紅外光譜表征。該方法已擴大實(shí)驗，適于工業(yè)化。 |
| 關(guān)鍵詞：磷�；�；水解；磷酸苯二鈉 |
| 中圖分類(lèi)號：R446.1 文獻標識碼：A 文章編號：1009-9212（2011）03-0036-04 |
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| Synthesis of Disodium Phenyl Phosphate |
| LI Yan-yun，YIN Zhen-yan*
（College of Chemical Engineering，Beijing Institute of Petro-Chemical Technology，Beijing 102617, China)） |
| Abstract：Disodium phenyl phosphate was synthesized using phenol, phosphorus oxychloride and sodium carbonate as starting materials. Factors influencing the reactions were studied and optimized. The overall yield was 69.2%. Best results of the phosphoryl reaction were obtained at a molar ratio of 1.0:1.1 (phenol:phosphorus oxychloride) and refluxed for 10 h at 130~140℃. The target product was identified by melting point, elemental analysis and IR. This method has been magnified and industrialized. |
| Key words：phosphoryl；hydrolysis；neutralization；disodium phenyl phosphate |
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作者簡(jiǎn)介：李艷云（1964-），女，吉林松原人，副教授，研究方向：精細化工。（E-mail：liyanyun@bipt.edu.cn）
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聯(lián) 系 人： 尹振晏，研究方向：精細化工。（E-mail：yinzhenyan@bipt.edu.cn）
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收稿日期：2011-04-26
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