| 第 32 卷第 1 期 |  | Vol. 32 No. 1 | | 2002 年 2 月 | Feb 2002 |
|
所屬欄目：其它
1,2,3-三氮唑的合成工藝研究 |
| 肖國民; 楊為華; 宋文哲; 譚仁賓(東南大學(xué)化學(xué)化工系; 江蘇南京) |
| 摘 要：以對甲苯磺酰肼為原料合成 1,2 ,3 三氮唑。研究了各種工藝條件對收率的影響 ,獲得了較佳合成工藝 :用苯作溶劑 ,對甲苯磺酰氯與水合肼配比為 1∶2 (mol) ,在 60～ 70℃下進(jìn)行縮合反應制得對甲苯磺酰肼 ,收率為 80 6% ;對甲苯磺酰肼與乙二醛以配比 1∶2 7(mol)反應后 ,通入定量的氨氣進(jìn)行環(huán)合反應生成 1,2 ,3 三氮唑 ,收率達 66 8% |
| 關(guān)鍵詞：1; 2; 3三氮唑; 對甲苯磺酰肼; 合成; β內酰胺抗生素 |
| 中圖分類(lèi)號：TQ465 文獻標識碼：A 文章編號：1009-9212(2002)01-0014-02 |
|
| Study on Synthesis of 1,2,3-triazole. XIAO Guo-min, et al. |
| Department of Chemistry and Chemical Engineering; Southeast University; Nanjing; 210096） |
| Abstract：Some synthetic methods of 1,2,3 triazole were introduced in this article. The process of preparation from p toluene sulfonyl hydrazine was selected for its advantages.Experiments were done to compare the different conditions of reaction, and the optimal condition to synthesis of 1,2,3 triazole was obtained as follows: p toluene sulfonyl hydrazine was prepared by reaction of MeC 6H 4SO 2Cl (a) with H 2NNH 2·H 2O(b) in presence of benzene as solvent and M ratio of a∶b=1∶2 at 60～70℃. Then high purity... |
| Key words：triazole; p toluene sulfonyl hydrazine; synthesis; β lactam antibiotics |
|
收稿日期：2001-10-12
|
| 閱讀全文 |
|