| 第 44 卷第 2 期 |  | Vol. 44 No. 2 | | 2014 年 4 月 | Apr 2014 |
|
所屬欄目：分析與測試
毛細管氣相色譜法測定倍他米松中有機溶劑殘留量 |
| 肖理紅，曹遠尼，胡薏冰，彭紅建*
（中南大學(xué) 化學(xué)化工學(xué)院， 湖南 長(cháng)沙 410083） |
| 摘 要：建立了倍他米松中溶劑殘留量的分離測定方法。采用氣相色譜法，以氮氣為載氣，FID檢測器，KB-5毛細管柱，程序升溫，外標法測定倍他米松中甲醇、丙酮、二氯甲烷和甲苯及N，N-二甲基甲酰胺的殘留量。5種有機溶劑完全分離，在所考察的濃度范圍內具有良好的線(xiàn)性，r=0.999 4~0.999 9，平均回收率97.48%~102.24%，精密度RSD小于5%，檢測限0.03~0.10 μg／mL。所建立的方法快速、靈敏、準確，可用于倍他米松中有機溶劑殘留量的測定。 |
| 關(guān)鍵詞：倍他米松；有機溶劑殘留；氣相色譜 |
| 中圖分類(lèi)號：0657.7 文獻標識碼：B 文章編號：1009-9212（2014）02-0070-03 |
|
| Determination of Residual Organic Solvents in Betamethasone by Gas Chromatography |
| XIAO Li-hong, CAO Yuan-ni, HU Yi-bing, PENG Hong-jian*
(School of Chemistry and Chemical Engineering in Central South University, Changsha 410083, China) |
| Abstract：A method for determination of five residual organic solvents in betamethasone was established. All the residual solvents in betamethasone are methanol, acetone, carrene, toluene and N,N-dimethylformamide which were quantitatively determined by GC on KB-5 column with FID detector and nitrogen as the carrier. The solvents were completely separated. There was a good linearity (r=0.9994~0.9999). The RSD of precision was less than 5%. The average recovery rate was in the range of 97.4%~102.1%. The detection limit was between 0.03~0.10 μg/mL. The method is rapid, sensitive and accurate. |
| Key words：betamethasone; residual solvent; GC |
|
基金項目：湖南省科技廳資助項目（2010RS4015），中南大學(xué)貴重儀器設備共享基金資助（CSUZC2014020）。
|
作者簡(jiǎn)介：肖理紅（1975-），男，湖南湘潭人，講師，主要從事藥物化學(xué)的研究工作。
|
聯(lián) 系 人：彭紅建，副教授（E-mail：phj108@163.com）。
|
收稿日期： 2014-04-0
|
|