| 第 32 卷第 2 期 |  | Vol. 32 No. 2 | | 2002 年 4 月 | Apr 2002 |
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所屬欄目：其它
4-氟-2-氯苯胺的合成研究 |
| 宋廣亮; 朱紅軍; 王錦堂(南京工業(yè)大學(xué)理學(xué)院; 江蘇南京) |
| 摘 要：介紹了以 4 氟苯胺為原料 ,通過(guò)乙�；�、氯代、水解三步制備 4 氟 2 氯苯胺的方法 ,對主要的影響因素作了考察并得出結論 :乙�；磻獪囟葢∮� 30℃ ;氯代中 2 /SO2 Cl2為 1∶0 9(mol/mol)時(shí)較好 ;在水解階段鹽酸濃度控制在 4mol/L較佳 ,4 氟 2 氯苯胺的純度大于 99% ,總收率達到 70 % |
| 關(guān)鍵詞：氟苯胺; 乙�；磻�; 4氟2氯苯胺; 氯代 |
| 中圖分類(lèi)號：TQ246.3 文獻標識碼：A 文章編號：1009-9212(2002)02-0018-02 |
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| A Study on the Preparation of 2-Chloro-4-Fluoroaniline. |
| Song Guang liang; et al（School of Science; Nanjing University of Technology; Nanjing 210009; China） |
| Abstract：The 2 chloro 4 fluoroaniline was prepared from 4 fluoroaniline by acetylation, chlorination,hydrolysis it. The effect of the reaction conditions was also invertigated,the temperature of acetylation is lower than 30℃,mole ration of Ⅲ and SO 2Cl 2 is 1∶0.9, the HCl is 4mol/l in hydrolysis.The total yield is 70% and purity is up to 99%. |
| Key words：fluoroaniline; acetylation; 2 chloro 4 fluoroaniline; chlorination |
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收稿日期：2001-10-18
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