| 第 45 卷第 1 期 |  | Vol. 45 No. 1 | | 2015 年 2 月 | Feb 2015 |
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所屬欄目：農藥及中間體
2，5-二氯-4-氨基苯酚的合成 |
| 嚴小麗
（上海石化工業(yè)學(xué)校，上海 201512） |
| 摘 要：以對二氯苯為原料，經(jīng)硝化、水合肼催化還原、Bamberger重排等反應合成了2，5-二氯-4-氨基苯酚；并對水合肼催化還原和Bamberger重排反應的條件進(jìn)行了優(yōu)化。在優(yōu)化的條件下，2，5-二氯苯胲的收率達96.1%，2，5-二氯-4-氨基苯酚的收率達53.1%。該合成工藝具有反應周期短、條件溫和、收率高和后處理簡(jiǎn)單等優(yōu)點(diǎn)，有產(chǎn)業(yè)化前景。 |
| 關(guān)鍵詞：2，5-二氯-4-氨基苯酚；水合肼；催化還原；Bamberger重排 |
| 中圖分類(lèi)號：TQ460.3 文獻標識碼：A 文章編號：1009-9212（2015）01-0028-03 |
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| Synthesis of 2,5-Dichloro-4-aminophenol |
| YAN Xiao-li
(Shanghai Petrochemical Academy, Shanghai 201512, China) |
| Abstract：2,5-Dichloro-4-aminophenol was synthesized using 1,4-dichlorobenzene as the starting material followed by nitration reaction, catalytic reduction with hydrazine hydrate and Bamberger rearrangement. The optimal reaction conditions for catalytic reduction with hydrazine hydrate and Bamberger rearrangement were evaluated. Under the optimal conditions, the yields of 2,5-dichlorobenzene hydroxylamine and 2,5-dichloro-4-aminophenol were 96.1% and 53.1%, respectively. The synthetic process was proved to be with many advantages including mild reaction conditions, high yield, and simple treatment for products. |
| Key words：2,5-Dichloro-4-aminophenol; hydrazine hydrate; catalytic reduction; Bamberger rearrangement |
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作者簡(jiǎn)介：嚴小麗（1983-），女，江蘇泰州人，講師，碩士，主要從事精細化工中間體研究（E-mail：yanxiaoli-1983@163.com）。
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收稿日期： 2014-12-2
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