| 第 45 卷第 2 期 |  | Vol. 45 No. 2 | | 2015 年 4 月 | Apr 2015 |
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所屬欄目：醫藥及中間體
一種2，6-二甲基苯甲酸的改進(jìn)合成方法 |
| 陳 磊
（天津硯津科技有限公司，天津 300143） |
| 摘 要：以2，6-二甲基苯胺為原料，通過(guò)重氮化反應制備2，6-二甲基苯腈，經(jīng)水蒸汽蒸餾法提純后，采用75%硫酸酸化，再經(jīng)酸堿法對產(chǎn)物進(jìn)行脫色和純化得產(chǎn)物2，6-二甲基苯甲酸，總收率68.4%。工藝簡(jiǎn)單、操作安全、適合工業(yè)化生產(chǎn)。 |
| 關(guān)鍵詞：2，6-二甲基苯甲酸；水蒸汽蒸餾；2，6-二甲基苯腈；2，6-二甲基苯胺 |
| 中圖分類(lèi)號：O625.51+1 文獻標識碼：A 文章編號：1009-9212（2015）02-0056-02 |
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| An Efficient Method for the Preparation of 2,6-Dimethyl Benzoic Acid |
| CHEN Lei
(Tianjin Yanjin Technology Co., Ltd., Tianjin 300143, China) |
| Abstract：2,6-Dimethyl benzonitrile was synthesized by diazo reaction using 2,6-dimethyl aniline as starting material. The crude 2,6-dimethyl benzonitrile was further purified by steam distillation. The purified 2,6-dimethyl benzonitrile was acidized using 75% sulfuric acid, and the obtained crude 2,6-dimethyl benzoic acid was then decolorized and purified by acid-base method to give the target product. This simple and safe procedure is suitable for production in large scale. |
| Key words：2,6-dimethyl benzoic acid; steam distillation; 2,6-dimethyl benzonitrile; 2,6-dimethyl aniline |
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作者簡(jiǎn)介：陳 磊（1980-），男，河北唐山人，碩士，研究方向：高分子合成（E-mail：juliancl@163.com）。
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收稿日期：2015-01-31
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