| 第 45 卷第 3 期 |  | Vol. 45 No. 3 | | 2015 年 6 月 | Jun 2015 |
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所屬欄目：醫藥及中間體
麻保沙星微囊制備方法 |
| 姜應新，鄭立斌，侯仲軻，邱家軍
（國邦醫藥化工集團有限公司，浙江 紹興 312369） |
| 摘 要：以辛烯基琥珀酸淀粉鈉為壁材，對麻保沙星進(jìn)行微囊化包埋。實(shí)驗條件為n（麻保沙星）∶n（混合溶劑）=1∶9，辛烯基琥珀酸淀粉鈉濃度20%，麻保沙星含量10%，真空度0.03 MPa，乳化剪切溫度40℃，滴加時(shí)間60 min。所得微囊包封率99.5%。此過(guò)程操作簡(jiǎn)單，提供了麻保沙星新劑型的制備方法。 |
| 關(guān)鍵詞：麻保沙星；微囊劑；辛烯基琥珀酸淀粉鈉 |
| 中圖分類(lèi)號：R969 文獻標識碼：A 文章編號：1009-9212（2015）03-0014-03 |
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| Preparation of Microcapsulated Marbofloxacin |
| JIANG Ying-xin, ZHEN Li-bing, HOU Zhong-ke, QIU Jia-jun
(Guobang Medicine and Chemical Industry Group Limited Company, Shaoxing 312369, China) |
| Abstract：Marbofloxacin was microencapsulated using octenylsuccinate sodium starch in this paper. The optimum experimental conditions are as following: the ratio of marbofloxacin to the mixed solvent is 1∶9; the concentration of octenylsuccinate sodium starch is 20%; the content of marbofloxacin is 10%; the vacuum is 0.03 MPa; the emulsification temperature is at 40℃; the adding period for octenylsuccinate sodium starch in dropping is 60 minutes. In a typical encapsulation process, the microencapsulated efficiency is up to 99.5%. This simple method offered a new process for the preparation of encapsulated marbofloxacin. |
| Key words：marbofloxacin; microcapsule; octenylsuccinate sodium starch |
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基金項目：國家科技部國際科技合作專(zhuān)項（2012DFA40940）。
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作者簡(jiǎn)介：姜應新（1980-），男，黑龍江綏化人，高級工程師，博士，研究方向：藥用輔料和半制劑。
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收稿日期： 2015-05-1
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