| 第 46 卷第 5 期 |  | Vol. 46 No. 5 | | 2016 年 10 月 | Oct 2016 |
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所屬欄目：醫藥及中間體
3，4-二羥基苯乙酮的合成 |
| 丁華琴，張玉嬌，蔣旭亮*
（沈陽(yáng)藥科大學(xué) 制藥工程學(xué)院，遼寧 沈陽(yáng) 110016） |
| 摘 要：研究了鄰苯二酚在不同條件下的Friedel-Crafts乙�；磻�。利用三氟化硼乙醚溶液作催化劑，乙酸為乙�；噭�，合成了3，4-二羥基苯乙酮，并在此基礎上，進(jìn)一步對反應條件進(jìn)行了優(yōu)化。優(yōu)化的條件為：n（三氟化硼）∶n（鄰苯二酚）=1.2∶1.0，反應溫度為80℃，反應時(shí)間為4 h，優(yōu)化條件下，3，4-二羥基苯乙酮的收率達66.7%。 |
| 關(guān)鍵詞：3，4-二羥基苯乙酮；三氟化硼；乙酸；乙�；磻� |
| 中圖分類(lèi)號：O625.42 文獻標識碼：A 文章編號：1009-9212（2016）05-0025-02 |
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| Synthesis of 3,4-Dihydroxyacetophenone |
| DING Hua-qin, ZHANG Yu-jiao, JIANG Xu-liang*
(College of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China) |
| Abstract：Friedel-Crafts acetylation reaction of catechol under different conditions was studied. 3,4-Dihydroxyacetophenone was synthesized using boron trifluoride/ethyl ether solution as catalyst and acetic acid as acetylation reagent, and the reaction conditions were further optimized. The optimized reaction conditions were as following: the molar ratio of BF3 to catechol was of 1.2; and the reaction temperature and time were 80℃ and 4 h, respectively. Under the optimized conditions, 3,4-dihydroxyacetophenone was obtained with a yield of 66.7%. |
| Key words：3,4-dihydroxyacetophenone; boron trifluoride; acetic acid; acetylation reaction |
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作者簡(jiǎn)介：丁華琴（1992-），女，江蘇東臺人，碩士研究生，研究方向：抗腫瘤藥物的開(kāi)發(fā)與研究。
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聯(lián) 系 人： 蔣旭亮，副教授，研究方向：新藥的設計、合成與活性研究（E-mail：xuliangjiang1975@163.com）。
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收稿日期：2016-09-26
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