| 第 48 卷第 1 期 |  | Vol. 48 No. 1 | | 2018 年 2 月 | Feb 2018 |
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所屬欄目：專(zhuān)論與綜述
4-苯甲�；�-L-苯基丙氨酸的合成方法研究進(jìn)展 |
| 趙 賽，史全全
（南京海辰藥業(yè)股份有限公司 合成研究部，江蘇 南京 210046） |
| 摘 要：4-苯甲�；�-L-苯基丙氨酸是含有二苯甲酮結構的非天然氨基酸。其所含的二苯甲酮結構在特定紫外光線(xiàn)波長(cháng)照射下能夠發(fā)生電子躍遷，并和鄰近大分子（比如蛋白質(zhì)）中的氨基酸殘基形成共價(jià)鍵，起到了對大分子中特定結構位置的定位作用。依照時(shí)間的先后，對目前所報道4-苯甲�；�-L-苯基丙氨酸的合成方法進(jìn)行了綜述。比較了它們各自的優(yōu)缺點(diǎn)，并提出可能的改進(jìn)方法，對實(shí)際合成工作具有指導意義。 |
| 關(guān)鍵詞：光親和標記技術(shù)；二苯甲酮；氨基酸；4-苯甲�；�-L-苯基丙氨酸 |
| 中圖分類(lèi)號：O6-1 文獻標識碼：B 文章編號：1009-9212（2018）02-0005-03 |
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| Progress in the Preparation of L-4-Benzoylphenylalanine |
| ZHAO Sai, SHI Quan-quan
（Department of Chemical Synthesis, Nanjing Hicin Pharmaceutical Co., Ltd., Nanjing 210046, China） |
| Abstract：L-4-Benzoylphenylalanine is synthetic amino acid containing the structure of benzophenone. Upon irradiation at the relevant wavelength, benzophenone will generate a triplet ketyl biradical that can react with protein functional groups to form covalent bonds, thereby functioning as a label to locate the specific structure in the macromolecule. In response to this magnificent trait, the method development of the synthesis of L-4-benzoylphenylalanine was definitely worthwhile and also received extensive attentions. In this article, current methods used to synthesize this compound were reviewed to compare their respective characteristics, which had a guiding significance for the practical work. |
| Key words：photoaffinity labeling; benzophenone; amino acid; L-4-benzoylphenylalanine |
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作者簡(jiǎn)介：趙 賽（1980-），男，江蘇無(wú)錫人，博士，主要從事藥物及中間體的合成及工藝優(yōu)化（E-mail：z_s_1980@hotmail.com）。
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收稿日期：2018-02-09
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