| 第 48 卷第 1 期 |  | Vol. 48 No. 1 | | 2018 年 2 月 | Feb 2018 |
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所屬欄目：醫藥及中間體
16-鹵代苯亞甲基去氫表雄酮的合成及結構表征 |
| 梁光平，楊 俊，聶昌平，陳東林，丁麗娜，萬(wàn)路平
（遵義醫藥高等專(zhuān)科學(xué)校 藥學(xué)系，貴州 遵義 563006） |
| 摘 要：以去氫表雄酮和鹵代苯甲醛為起始原料，在氫氧化鉀和乙醇反應體系條件下以74.8%~98.1%的收率合成了9個(gè)16-鹵代苯亞甲基去氫表雄酮衍生物。所有目標產(chǎn)物均未見(jiàn)文獻報道，其結構經(jīng)MS、1H NMR及元素分析表征確證。 |
| 關(guān)鍵詞：去氫表雄酮；鹵代苯甲醛；衍生物 |
| 中圖分類(lèi)號：R914.4 文獻標識碼：A 文章編號：1009-9212（2018）02-0045-04 |
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| Synthesis and Structural Characterization of 16-(Halogenated Benzylidene) Derivatives of |
| LIANG Guang-ping, YANG Jun, NIE Chang-ping, CHEN Dong-lin, DING Li-na, WAN Lu-ping
(Department of pharmacy, Zunyi Medical and Pharmaceutical College, Zunyi 563006, China) |
| Abstract：Nine 16-(halogenated benzylidene) derivatives of dehydroepiandrosterone, which were not reported in the literature, were synthesized using dehydroepiandrosterone and corresponding halobenzaldehydes as start materials, potassium hydroxide as the catalyst, and ethanol as the solvent. The yields for the target derivatives were in the range between 74.8% and 98.1%. The structures of products were confirmed using MS, 1H NMR and elemental analysis. |
| Key words：dehydroepiandrosterone; halobenzaldehyde; derivatives |
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基金項目：遵義醫藥高等專(zhuān)科學(xué)校博士科研啟動(dòng)項目（遵醫專(zhuān)科合BS2018001號）。
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作者簡(jiǎn)介：梁光平（1988-），男，貴州赤水人，博士，研究方向：天然產(chǎn)物的結構修飾（E-mail：guangping_liang@aliyun.com）。
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收稿日期：2018-02-08
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