| 第 48 卷第 3 期 |  | Vol. 48 No. 3 | | 2018 年 6 月 | Jun 2018 |
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所屬欄目：專(zhuān)論與綜述
JAK抑制劑在類(lèi)風(fēng)濕性關(guān)節炎治療中的研究進(jìn)展 |
| 張溢凡
（中國人民解放軍93575部隊 衛生隊，河北 承德 067000） |
| 摘 要：Janus激酶（JAK）是一種非受體酪氨酸蛋白激酶，參與體內眾多重要的生物學(xué)過(guò)程，是一條重要的細胞內信號轉導通路。研究表明，由其介導的通路通常與炎癥性疾病、皮膚性疾病及其他自身免疫性疾病有關(guān)，JAK已逐漸成為治療這些疾病的重要靶標。主要綜述了JAK的結構與功能、JAK-STAT信號通路在治療RA中的調控作用以及近年來(lái)JAK抑制劑的研究進(jìn)展，旨在為以JAK為靶點(diǎn)的藥物研發(fā)提供參考。 |
| 關(guān)鍵詞：JAK抑制劑；類(lèi)風(fēng)濕性關(guān)節炎（RA）；研究進(jìn)展 |
| 中圖分類(lèi)號：R971 文獻標識碼：B 文章編號：1009-9212（2018）03-0010-05 |
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| Research Progress of JAK Inhibitors in the Treatment of Rheumatoid Arthritis |
| ZHANG Yi-fan
(Health Unit of 93575 Troop, People's Liberation Army of China, Chengde 067000, China) |
| Abstract：Janus kinase (JAK), a non-receptor tyrosine kinase, participated in many important biological processes in vivo and was an important intracellular signal transduction pathway. It was observed that the pathways mediated by JAKs were associated with inflammatory diseases, dermatologic diseases, and other autoimmune diseases, and JAKs were the important targets for the treatment of these diseases. This review mainly discussed the structure and function of JAKs, and the role of the JAK-STAT signaling pathway in treating RA. Meanwhile, the development of JAK inhibitors in recent years was also described, focusing on providing effective reference for researching new drugs based on JAK. |
| Key words：JAK inhibitor; rheumatoid arthritis (RA); research progress |
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作者簡(jiǎn)介：張溢凡（1991-），男，河南鄭州人，藥師，主要從事生物技術(shù)研究（E-mail：149889071@qq.com）。
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收稿日期：2018-06-12
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