| 第 48 卷第 3 期 |  | Vol. 48 No. 3 | | 2018 年 6 月 | Jun 2018 |
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所屬欄目：醫藥及中間體
溴代丙酮酸的合成新工藝 |
| 黃子涵1，邵國光1*，胡 能2
（1. 長(cháng)沙市第二十一中學(xué)，湖南 長(cháng)沙 410000；2. 長(cháng)沙理工大學(xué) 化學(xué)與生物工程學(xué)院，湖南 長(cháng)沙 410114） |
| 摘 要：以丙酮酸和二溴海因為原料制備了溴代丙酮酸。優(yōu)化工藝條件為：反應溫度為50℃，催化劑為對甲苯磺酸，溶劑為甲醇，收率為40%。該新工藝具有操作友好、后處理簡(jiǎn)單等優(yōu)勢。 |
| 關(guān)鍵詞：丙酮酸；二溴海因；溴代丙酮酸 |
| 中圖分類(lèi)號：O632 文獻標識碼：A 文章編號：1009-9212（2018）03-0031-02 |
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| A Novel Synthetic Process for the Preperation of Brominated Pyruvic Acid |
| HUANG Zi-han1, SHAO Guo-guang1*, HU Neng2
(1. NO. 21 Middle School of Changsha, Changsha 410000, China; 2. Changsha University of Science and Engineering, College of Chemical and Biological Engineering, Changsha 410114, China) |
| Abstract：Brominated pyruvic acid is an important intermediate, which is synthesized using pyruvic acid and dibromohydantoin as the raw materials. The yield of brominated pyruvic acid is of 40% under the optimum conditions including reaction temperature of 50℃, p-toluene sulphonic acid as catalyst, and methanol as solvent. This novel process has advantages of friendly operation and simple post-processing. |
| Key words：pyruvic acid; dibromohydantoin; brominated pyruvic acid |
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作者簡(jiǎn)介：黃子涵（2001-），男，湖南長(cháng)沙人。
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聯(lián) 系 人：邵國光，特級教師，從事化學(xué)教育研究（E-mail：shao631226@126.com）。
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收稿日期：2018-05-20
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