| 第 48 卷第 5 期 |  | Vol. 48 No. 5 | | 2018 年 10 月 | Oct 2018 |
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所屬欄目：醫藥及中間體
微波技術(shù)下肉桂酸合成工藝研究 |
| 蔡旭婷，毛琳怡，張?chǎng)蝹�，李晨帆，胡鴻�?
（浙江師范大學(xué) 行知學(xué)院，浙江 金華 321004） |
| 摘 要：微波輻射下，以無(wú)水碳酸鉀作為催化劑，苯甲醛、乙酸酐為原料合成肉桂酸。采用1H NMR對產(chǎn)物進(jìn)行表征�？疾炝溯椛涔β�、輻射時(shí)間、催化劑的用量對肉桂酸收率的影響。優(yōu)化反應條件為，輻射功率450 W，輻射時(shí)間30 min，無(wú)水碳酸鉀用量為8%。優(yōu)化條件下，收率達70.0%以上。 |
| 關(guān)鍵詞：肉桂酸；微波輻射；催化合成 |
| 中圖分類(lèi)號：O621.25 文獻標識碼：A 文章編號：1009-9212（2018）05-0022-03 |
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| Application of Microwave Technology in the Synthesis of Cinnamic Acid |
| CAI Xu-ting, MAO Lin-yi , ZHANG Xin-wei, LI Chen-fan1, HU Hong-yu*
(Xingzhi College of Zhejiang Normal University, Jinhua 321004, China) |
| Abstract：Cinnamic acid was synthesized from the reaction of benzaldehyde with acetic anhydride using anhydrous potassium carbonate as catalyst under microwave irradiation. The products were characterized by 1H NMR. The effects of factors including radiation power, radiation time and amount of catalyst on the yield of cinnamic acid were investigated. The results showed that the optimum reaction conditions were as the following: radiation power of 450 W; radiation time of 30 min; dosage of anhydrous potassium carbonate of 8%, and yield was over 70.0%. |
| Key words：cinnamic acid; microwave radiation; catalyzed synthesis |
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基金項目：浙江師范大學(xué)實(shí)驗技術(shù)開(kāi)發(fā)資助項目（SJ201824），浙江省高校實(shí)驗室工作研究項目（ZD201813）。
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作者簡(jiǎn)介：蔡旭婷（1998-），女，浙江東陽(yáng)人，主要從事有機合成研究。
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聯(lián) 系 人：胡鴻雨，主要從事有機合成研究工作（E-mail：huhongyu22@126.com）。
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收稿日期：2018-08-09
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