| 第 48 卷第 6 期 |  | Vol. 48 No. 6 | | 2018 年 12 月 | Dec 2018 |
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所屬欄目：醫藥及中間體
新型固相催化劑催化環(huán)氧化物與芳香氨的開(kāi)環(huán)反應 |
| 代 佳
（紅河衛生職業(yè)學(xué)院 藥學(xué)系，云南 蒙自 661100） |
| 摘 要：以固定于Merrifield樹(shù)脂的聚乙烯亞胺（PEI）為載體，通過(guò)聚乙烯亞胺（PEI）上氨基與三氟甲磺酸鈧Sc（OTf）3的配位作用制備了固載的Sc（OTf）3 催化劑，并將其應用于催化環(huán)氧化物與芳香氨的開(kāi)環(huán)反應，獲得了重要的有機合成中間體2-氨基醇類(lèi)化合物。固載的催化劑能夠循環(huán)3次，更多次的循環(huán)導致反應收率下降。 |
| 關(guān)鍵詞：催化劑固載；聚乙烯亞胺；三氟甲磺酸鈧；環(huán)氧化物；芳香胺 |
| 中圖分類(lèi)號：O621.3 文獻標識碼：A 文章編號：1009-9212（2018）06-0030-03 |
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| The Ring-opening of Epoxides and Aromatic Amine Using Novel Catalyst |
| DAI Jia
(Pharmacy Department, Honghe Health Vacational College, Mengzi 661100, China) |
| Abstract：In this paper, a new solid support was prepared by anchoring polyethylenimine to Merrifield resin. Sc(OTf)3 was immoblized on this supporter by the coordination of Sc3+ with amino groups of polyethylenimine. The supported Sc(OTf)3 catalyst was tested in the ring-opening reaction of epoxides with aromatic amines, and 2-amino alcohols were obtained in good yields. The catalyst could be recycled for three times without decrease of the yield, but the catalytic activity was found to be decreased sharply after three recycles. |
| Key words：immobilization of catalyst; polyethylenimine; scandium trifluoromethanesulfonate; epoxide; aromatic amine |
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作者簡(jiǎn)介：代 佳（1982 -），女，云南蒙自人，講師，碩士研究生，研究方向：有機合成，藥物化學(xué)（E-mail：75746087@qq.com）。
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收稿日期：2018-11-18
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