| 第 49 卷第 5 期 |  | Vol. 49 No. 5 | | 2019 年 10 月 | Oct 2019 |
|
所屬欄目：農藥及中間體
基于正交試驗優(yōu)化研究乙草胺通氨醇解工藝 |
| 陳朋朋，胡先明，蔣慧華，王 雨
（江蘇萊科作物保護有限公司，江蘇 南通 226400） |
| 摘 要：對乙草胺的合成工藝路線(xiàn)進(jìn)行了研究。通過(guò)對乙草胺通氨醇解工段：2-甲基-6-乙基-N-氯甲基-α-氯乙酰苯胺加入乙醇后醇解、通氨合成乙草胺進(jìn)行正交試驗，確定了溶劑加入量為1∶3、醇解溫度為35℃、醇解時(shí)間為4 h、通氨溫度為20℃、終點(diǎn)pH值為8時(shí)，反應單步收率達98.5%。后處理后產(chǎn)品的含量和色澤在國內同行均處于領(lǐng)先水平。 |
| 關(guān)鍵詞：乙草胺；合成；正交試驗；工藝優(yōu)化 |
| 中圖分類(lèi)號：TQ455 文獻標識碼：A 文章編號：1009-9212（2019）05-0015-04 |
|
| Study on the Process of Inducing Ammonia into Acetochlor and the Alcoholysis Reaction Based on Orthogonal Experiment Test |
| CHEN Peng-peng, HU Xian-ming, JIANG Hui-hua, WANG Yu
(Jiangsu Laike Crop Protection Co.,Ltd., Nantong 226400, China) |
| Abstract：This article reported a research on the synthesis of acetochlor. Through the orthogonal experiment test on inducing ammonia into acetochlor and the alcoholysis reaction by adding 2-methyl-6-ethyl-N-chloromethyl-α-acetylchloroaniline to ethyl alcohol, the conditons of orthogonal test were obtained as followings: the proprtion of the solvent was of 1∶3, the temperature of the alcoholysis reaction was of 35℃, the reaction time was of 4 hours, the temperature of adding ammonia was of 20℃and the pH value was of 8. The yield of single-step reaction of acetochlor was above 98.5%. After this orthogonal experiment, the quality and appearance of the products are ranking the top of the industry. |
| Key words：acetochlor; synthesis; orthogonal test; process optimization |
|
作者簡(jiǎn)介：陳朋朋（1986-），男，江蘇南通人，工程師，研究方向：化工技術(shù)的研究與開(kāi)發(fā)。
|
收稿日期：2019-05-23
|
|