| 第 50 卷第 3 期 |  | Vol. 50 No. 3 | | 2020 年 6 月 | Jun 2020 |
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所屬欄目：農藥及中間體
AgNO3促進(jìn)4-芳基喹啉化合物的合成研究 |
| 陳嘉靚，蔣 俊*，于賢勇*
（理論有機化學(xué)與功能分子教育部重點(diǎn)實(shí)驗室，湖南科技大學(xué) 化學(xué)化工學(xué)院，湘潭 湖南 411201） |
| 摘 要：以N-芳基苯丙炔胺為原料，在A(yíng)gNO3作用下，通過(guò)熱環(huán)化以45%~92%的較高收率得到14種4-苯基喹啉類(lèi)衍生物。系統研究了溶劑、催化劑、溫度等因素對環(huán)化結果的影響，優(yōu)化了反應條件。合成策略具有反應條件溫和、操作簡(jiǎn)單、收率較高等特點(diǎn)，是一種合成4-苯基喹啉衍生物的新方法。 |
| 關(guān)鍵詞：苯胺；N-芳基苯丙炔胺；4-芳基喹啉；硝酸銀 |
| 中圖分類(lèi)號：O626.3 文獻標識碼：A 文章編號：1009-9212（2020）03-0030-06 |
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| Synthesis of 4-Arylquinoline Derivatives Using Silver Nitrate as the Promoter |
| CHEN Jia-liang, JIANG Jun*, YU Xian-yong*
(Key Laboratory of Theoretical Organic Chemistry and Functional Molecules, Ministry of Education, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201, China) |
| Abstract：A series of 4-arylquinoline derivatives were obtained with high yields by thermal cyclization reactionusing N-arylphenylpropynylamine as a starting material and AgNO3 as the catalyst. Factors including solvents, catalysts, temperature affecting the cyclization yield were evaluated. Based on the experimental results, the best reaction conditionswereobtained.In this paper, the synthetic strategy had many advantages includingmild reaction condition, simple operation, and high yield and could be a novelmethod forthe synthesis of 4-phenylquinoline. |
| Key words：aniline; N-propargylanilines; 4-arylquinolinederivatives; AgNO3 |
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基金項目：湖南省教育廳重點(diǎn)項目（18A192）。
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作者簡(jiǎn)介：陳嘉靚（1995-），男，湖南湘潭人，碩士研究生，研究方向：化學(xué)工藝（E-mail：light953189361@qq.com）。
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聯(lián) 系 人：蔣俊，講師，博士，研究方向：有機合成（E-mail：1060151@hnust.edu.cn）；于賢勇，教授，博士，研究方向：有機合成（E-mail：yu_xianyong@163.com）。
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收稿日期：2020-05-20
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