| 第 50 卷第 4 期 |  | Vol. 50 No. 4 | | 2020 年 8 月 | Aug 2020 |
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所屬欄目：醫藥及中間體
松香基Schiff堿雜環(huán)衍生物的合成及抑菌活性 |
| 伍 勇1，2，黃春花1，徐 靜1
（1. 四川衛生康復職業(yè)學(xué)院 藥學(xué)系，四川 自貢 643000；2. 江西農業(yè)大學(xué) 園林與藝術(shù)學(xué)院，江西 南昌330045） |
| 摘 要：脫氫樅胺及降解脫氫樅胺分別與雜環(huán)甲醛在乙醇溶劑中縮合合成了6個(gè)松香基Schiff堿雜環(huán)衍生物（a1／a2、b1／b2、c1／c2），并對產(chǎn)物結構進(jìn)行了IR、1H NMR光譜表征確證。通過(guò)體外最低抑菌活性測試，結果表明，化合物c1和c2對金黃色葡萄球菌（Staphylococcus aureus）、表皮葡萄球菌（Staphylococcus epidermidis）、綠膿桿菌（Pseudomonas aeruginosa）和產(chǎn)氣桿菌（Bacterium aerogenes）具有顯著(zhù)效果，其最低抑菌濃度（the Minimum Inhibitory Concentration）均為32 μg·mL-1。 |
| 關(guān)鍵詞：脫氫樅胺；降解脫氫樅胺；Schiff堿；合成；抑菌活性 |
| 中圖分類(lèi)號：R977.4 文獻標識碼：A 文章編號：1009-9212（2020）04-0030-04 |
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| Synthesis and Antibacterial Activity of Rosin-based Heterocyclic Schiff Bases |
| WU Yong1,2, HUANG Chun-hua1, XU Jing1
(1. Department of Pharmacy, Sichuan Vocational College of Health and Rehabilitation, Zigong 643000, China; 2. College of Landscape Architecture and Art, Jiangxi Agriculture University, Nanchang 330045, China) |
| Abstract：Using ethanol as solvent six rosin-based heterocyclic Schiff bases were synthesized from the condensation reaction between dehydroabietylamine or nor-dehydroabietylamine and heterocyclic formaldehyde. Their structures were confirmed by IR and 1H NMR spectroscopy. The minimum antibacterial activities of six compounds were tested by extracorporeal experiment. The results showed that compounds (c1 and c2) were relatively ideal and their least MICs of Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa,and Bacterium aerogenes was 32 μg·mL-1. |
| Key words：dehydroabietylamine; nor-dehydroabietylamine; Schiff base; synthesis; antibacterial activity |
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基金項目：國家林業(yè)局林業(yè)公益性行業(yè)科研專(zhuān)項（200704008），自貢市重點(diǎn)科技計劃資助項目（2018CZ30）。
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作者簡(jiǎn)介：伍 勇（1975—），男，四川榮縣人，副教授，碩士，主要從事天然產(chǎn)物化學(xué)研究（E-mail：wuyongrx@163.com）。
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收稿日期：2020-06-24
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