| 第 50 卷第 5 期 |  | Vol. 50 No. 5 | | 2020 年 10 月 | Oct 2020 |
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所屬欄目：專(zhuān)論與綜述
茴香硫醚的合成及應用進(jìn)展 |
| 董永銘，王 銳，李 飛，宮 紅，姜 恒*
（遼寧石油化工大學(xué) 石油化工學(xué)院，遼寧 撫順 113001） |
| 摘 要：介紹了茴香硫醚的不同合成路線(xiàn)，苯硫酚S-甲基化和在固定床中的連續催化合成，分析各種合成路線(xiàn)的優(yōu)缺點(diǎn)與適用條件，同時(shí)簡(jiǎn)述了茴香硫醚在有機合成、藥物合成、化學(xué)毒劑模擬劑、光引發(fā)劑等領(lǐng)域的應用。指出以碳酸二甲酯或甲醇作為甲基化試劑的苯硫酚S-甲基化反應是合成茴香硫醚的較優(yōu)合成工藝，在采用固定床反應器在多相催化的條件下，其連續操作、易分離等特點(diǎn)規避了原料苯硫酚及茴香硫醚自身毒性的影響，是未來(lái)茴香硫醚的綠色合成工藝發(fā)展方向。 |
| 關(guān)鍵詞：有機化合物；茴香硫醚；合成；應用 |
| 中圖分類(lèi)號：O625.72 文獻標識碼：B 文章編號：1009-9212（2020）05-0001-05 |
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| Progress in the Synthesis and Application of Thioanisole |
| DONG Yong-ming, WANG Rui, LI Fei, GONG Hong, JIANG Heng*
(School of Petrochemical Engineering, Liaoning Shihua University, Fushun 113001, China) |
| Abstract：The different synthetic routes of thioanisole were introduced including S-methylation of thiophenol and continuous catalytic synthesis of thioanisole in a fixed bed. Besides the analysis of the advantages and disadvantages of various synthetic routes, the application of thioanisole in organic synthesis, drug synthesis, chemical agent, photoinitiator and other fields was also briefly described. Finally, it was pointed out that the S-methylation of thiophenol using dimethyl carbonate or methanol as the methylation reagent was a promising synthesis process for thioanisole, which was affected by the raw material thiophenol and the toxicity of thiophenol itself. The use of fixed-bed reactor under the condition of heterogeneous catalysis, its continuous operation and easy separation can avoid the toxicity risk and it is the development direction of the green synthetic process of thioanisole in the future. |
| Key words：organic compound; thioanisole; synthesis; application |
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基金項目：遼寧省自然基金指導計劃項目（2019-ZD-0053）。
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作者簡(jiǎn)介：董永銘（1995—），男，遼寧撫順人，研究方向：綠色化學(xué)與催化。
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聯(lián) 系 人：姜 恒，教授，碩士生導師，研究方向：綠色化學(xué)與催化（E-mail：hjiang78@hotmail.com）。
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收稿日期：2020-09-03
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