| 第 50 卷第 5 期 |  | Vol. 50 No. 5 | | 2020 年 10 月 | Oct 2020 |
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所屬欄目：農藥及中間體
環(huán)保型殺菌劑啶酰菌胺的合成 |
| 尚 宇 ，李 飛，郭亞飛
（陜西省環(huán)境監測中心站，陜西 西安 710054） |
| 摘 要：研究了一種合成環(huán)保型殺菌劑啶酰菌胺的方法，并優(yōu)化其合成工藝。以鄰氯硝基苯和4-氯苯硼酸為原料，經(jīng)過(guò)Suzuki偶聯(lián)、還原、縮合3步反應合成啶酰菌胺。在優(yōu)化的反應條件下，3步總收率≥43%（以鄰氯硝基苯計），產(chǎn)物純度98%；產(chǎn)物結構經(jīng)IR、1H NMR、MS確證。第1步Suzuki偶聯(lián)反應中，優(yōu)化的反應條件是無(wú)水碳酸鉀作堿，催化劑四（三苯基膦）鈀的用量為15%（以鄰氯硝基苯計）。第2步還原反應溫度為50 ℃。該工藝簡(jiǎn)單經(jīng)濟，條件溫和，綠色環(huán)保。 |
| 關(guān)鍵詞：環(huán)保；殺菌劑；啶酰菌胺；合成 |
| 中圖分類(lèi)號：S482.2 文獻標識碼：A 文章編號：1009-9212（2020）05-0012-04 |
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| Green Synthesis of A New Environmental Friendly Fungicide Boscalid |
| SHANG Yu, LI Fei, GUO Ya-fei
(Shaanxi Environmental Monitoring Center, Xi'an 710054, China) |
| Abstract：A method for the synthesis of fungicide boscalid, a new environmental friendly bactericide was studied and the synthetic process was further optimized. Boscalid was prepared using 1-chloro-2-nitrobenzene and 4-chlorophenylboronic acid as starting materials through a series of reactions including Suzuki coupling reaction, reduction and condensation. Under the optimal reaction conditions, the total yield of boscalid was over 43% based on 1-chloro-2-nitrobenzene with a purity of 98%. The structure was confirmed by IR, 1H NMR, MS. In the first step, K2CO3 being used as alkali, 15% of catalyst Pd(PPh3)4 based on 1-chloro-2-nitrobenzen was used as the optimized condition. The optimal reaction temperature of the second reduction reaction is 50 ℃. This process is simple, mild, economical, and environmental friendly. |
| Key words：environmental friendly; boscalid; fungicide; synthesis |
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作者簡(jiǎn)介：尚 宇（1983—），男，遼寧撫順人，工程師，主要從事環(huán)境監測工作（E-mail：523588666@qq.com）。
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收稿日期：2020-07-31
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