| 第 50 卷第 5 期 |  | Vol. 50 No. 5 | | 2020 年 10 月 | Oct 2020 |
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所屬欄目：醫藥及中間體
脫氫樅基�；吝蚧衔锏暮铣膳c表征 |
| 伍 勇，黃春花，徐 靜
（四川衛生康復職業(yè)學(xué)院 藥學(xué)系，四川 自貢 643000） |
| 摘 要：以脫氫樅酸為原料，在二氯甲烷溶劑中與二氯亞砜�；铣擅摎錁乎Ｂ龋�2）；無(wú)水碳酸鈉作縛酸劑，脫氫樅酰氯（2）與80%水合肼在四氫呋喃溶劑中，常溫條件下生成脫氫樅酰肼（3）；脫氫樅酰肼（3）與乙酰丙酮經(jīng)三乙胺催化，在N，N-二甲基甲酰胺溶劑中回流8 h，最終脫水成環(huán)生成脫氫樅基�；吝蚧衔铮�1），收率43.3％。產(chǎn)物結構經(jīng)核磁共振氫譜、碳譜及紅外光譜確證。 |
| 關(guān)鍵詞：脫氫樅酸；吡唑；合成 |
| 中圖分類(lèi)號：TQ252.1 文獻標識碼：A 文章編號：1009-9212（2020）05-0021-03 |
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| Synthesis and Characterization of Dehydroabietyl Pyrazole Compound |
| WU Yong, HUANG Chun-hua, XU Jing
(Department of Pharmacy, Sichuan Vocational College of Health and Rehabilitation, Zigong 643000, China) |
| Abstract：Using dehydroabietic acid as raw material, dehydroabietic acid chloride (1) was synthesized in methylene chloride solvent with thionyl chloride; and then, anhydrous sodium carbonate as acid binding agent, dehydroabietic hydrazide (2) was prepared from product 1and 80% hydrazine hydrate in tetrahydrofuran solvent normal temperature conditions; the last, dehydroabietyl pyrazole compound(3), in yield of 43.3%, was obtained from product 2 and acetylacetone, which were catalyzed by triethylamine and were refluxed in N,N-dimethylformamide solvent for 8 hours; the product structure was characterized by IR, 1H NMR and 13C NMR. |
| Key words：dehydroabietic acid; pyrazole; synthesis |
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基金項目：自貢市重點(diǎn)科技計劃資助項目（2018CZ30），四川衛生康復職業(yè)學(xué)院重點(diǎn)項目（CWKY-2018Z-03）。
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作者簡(jiǎn)介：伍 勇（1975—），男，四川榮縣人，副教授，碩士，主要從事天然產(chǎn)物化學(xué)研究（E-mail：wuyongrx@163.com）。
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收稿日期： 2020-10-1
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