| 第 50 卷第 6 期 |  | Vol. 50 No. 6 | | 2020 年 12 月 | Dec 2020 |
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所屬欄目：醫藥及中間體
2，5-二甲�；秽c丙烯酸甲酯的選擇性單和雙MBH反應 |
| 王麗娟，何仙琴，羅 歡，丁宇浩，陳榮健，程傳杰*
（江西科技師范大學(xué) 化學(xué)化工學(xué)院，江西 南昌 330013） |
| 摘 要：以可再生資源為原料，利用高效原子經(jīng)濟性的反應設計合成了新的功能分子。首先以果糖為原料，一步合成2，5-二甲�；秽―FF），收率 41%；再以DFF 和丙烯酸甲酯為原料進(jìn)行Morita-Baylis-Hillmann（MBH）反應，在不同溶劑條件下選擇性合成單甲�；碗p甲�；映僧a(chǎn)物1 和2：以二氧六環(huán)-水（V∶V=1∶1）為溶劑可同時(shí)獲得單甲�；碗p甲�；l(fā)生MBH 反應的產(chǎn)物1 和2，收率分別為 46% 和 37%；以甲醇為溶劑則選擇性獲得單甲�；l(fā)生MBH 反應的產(chǎn)物1，收率 32%。產(chǎn)物用1H NMR進(jìn)行了結構表征確證。 |
| 關(guān)鍵詞：功能丙烯酸酯；MBH 反應；2，5-二甲�；秽―FF）；選擇性 |
| 中圖分類(lèi)號：O629.1 文獻標識碼：A 文章編號：1009-9212（2020）06-0037-04 |
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| Selective Mono- and Bis-MBH Reaction Between 2,5-Diformyl Furan and Methyl Acrylate |
| WANG Li-juan, HE Xian-qin, LUO Huan, DING Yu-hao, CHEN Rong-jian, CHENG Chuan-jie*
(School of Chemistry and Chemical Engineering, Jiangxi Science&Technology Normal University, Nanchang 330013, China) |
| Abstract：It is of great significance to synthesize functional molecules via highly efficient and atom-economic reactions by using renewable resource materials. Herein, firstly, 2,5-diformyl furan (DFF) was synthesized from fructose in one step with a yield of 41%. Then, MBH reactions were conducted between DFF and methyl acrylate,and selective products in different solvents were obtained. When 1,4-dioxane/water (V∶V=1∶1) was utilized, both mono-acrylate and di-acrylate products were obtained at yield of 46% and 37%, respectively; while the sole methanol solvent gave only mono-acrylate with a yield of 32%. All the products were characterized by 1H NMR. The synthesized functional acrylates may further undergo reactions to prepare more valuable small molecules as well as polymers. |
| Key words：functional acrylates; MBH reaction; 2,5-diformyl furan (DFF); selectivity |
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基金項目：國家自然科學(xué)基金項目 (21564004)，江西科技師范大學(xué)本科生創(chuàng )新科研項目。
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作者簡(jiǎn)介：王麗娟 (1998—)，女，內蒙古呼和浩特人，主要從事有機功能分子設計合成方面的研究（E-mail: 2569974376@qq.com）。
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聯(lián) 系 人：程傳杰，教授，博士，主要從事利用可再生資源設計合成有機功能分子方面的研究（E-mail: chengcj530@163.com）。
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收稿日期：2020-10-14
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