| 第 51 卷第 2 期 |  | Vol. 51 No. 2 | | 2021 年 4 月 | Apr 2021 |
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所屬欄目：專(zhuān)論與綜述
4′-羥基聯(lián)苯-4-甲酸合成工藝研究進(jìn)展 |
| 馬利娟，鄧 博
（西安萬(wàn)隆制藥股份有限公司，陜西 西安 710119） |
| 摘 要：綜述了以4-羥基聯(lián)苯、4-羥基-4′-氰基聯(lián)苯、4-羧基苯硼酸、4-羥基苯硼酸為原料制備4′-羥基聯(lián)苯-4-甲酸的四種合成方法，對每種合成工藝的優(yōu)缺點(diǎn)進(jìn)行分析，并介紹了其在構筑有機發(fā)光材料、液晶材料及其中間體、法尼醇X受體拮抗劑等領(lǐng)域合成中的應用，展望了4′-羥基聯(lián)苯-4-甲酸的應用前景。 |
| 關(guān)鍵詞：4′-羥基聯(lián)苯-4-甲酸；合成工藝；曲法羅汀 |
| 中圖分類(lèi)號：O634 文獻標識碼：B 文章編號：1009-9212（2021）02-0015-05 |
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| 4'-Hydroxy-4-biphenylcarboxylic Acid |
| MA Li-juan，DENG Bo
(Xi'an WanLong Pharmaceutical Co.,Ltd., Xi'an 710119,China) |
| Abstract：According to the different starting materials, the synthetic methods from 4-hydroxybiphenyl, 4-hydroxy-4'- cyanobiphenyl, 4-carboxyphenylboronic acid and 4-hydroxyphenylboronic acid were reviewed. The advantages and disadvantages of each synthesis process were discussed. Meanwhile the application status of 4'-hydroxy-4-biphenylcarboxylic acid in organic luminescent materials, liquid crystal materials and their intermediates, farnesoid X receptor antagonists were summarized. At the same time, the future application was prospected. |
| Key words：4'-hydroxy-4-biphenylcarboxylic acid; synthesis process; trifarotene |
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作者簡(jiǎn)介：馬利娟（1983—），女，陜西西安人，主管藥師，執業(yè)藥師，主要從事原料藥研發(fā)與項目立項、制劑開(kāi)發(fā)及藥品注冊工作。
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收稿日期：2021-01-20
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