| 第 51 卷第 3 期 |  | Vol. 51 No. 3 | | 2021 年 6 月 | Jun 2021 |
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所屬欄目：專(zhuān)論與綜述
淀粉微球作為藥物載體的應用研究進(jìn)展 |
| 問(wèn)娟娟1，劉浪浪2，高艷蓉1，張 爽1
（1.陜西國際商貿學(xué)院 醫藥學(xué)院 陜西省中藥綠色制造技術(shù)協(xié)同創(chuàng )新中心，陜西 咸陽(yáng) 712046；2. 陜西寶塔山油漆股份有限公司，陜西 興平 713100） |
| 摘 要：淀粉微球因具有無(wú)毒性、良好的生物相容性以及能被細胞吸收等優(yōu)點(diǎn)，是生物醫藥領(lǐng)域藥物載體研究熱點(diǎn)之一�？偨Y了國內外構建淀粉微球作為藥物載體的研究成果，分析了淀粉微球中淀粉的來(lái)源主要有玉米淀粉、馬鈴薯淀粉、木薯淀粉等，概述了淀粉微球作為藥物載體的應用，指出淀粉微球作為藥物載體存在的問(wèn)題及淀粉微球藥物載體的發(fā)展前景和方向，旨在為淀粉微球藥物載體在藥物釋放可控性、規�；芭R床應用安全性等方面提供有價(jià)值的參考。 |
| 關(guān)鍵詞：淀粉微球；藥物載體；制備；應用 |
| 中圖分類(lèi)號：O63 文獻標識碼：B 文章編號：1009-9212（2021）03-0001-05 |
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| Research Progress of Starch Microspheres as Drug Carriers |
| WEN Juan-juan1, LIU Lang-lang2, GAO Yan-rong1, ZHANG Shuang1
(1.School of Pharmacy, Shaanxi Institude of International Trade & Commerce, Collaborative Innovation Center of Green Manufacturing Technology for Traditional Chinese Medicine in Shaanxi Province, Xianyang 712046, China; 2. Shaanxi Baotashan Paint Co., Ltd., Xingping 713100, China) |
| Abstract：Starch microspheres have attracted the attention of many experts and scholars as drug carriers in biomedical field because of their advantages of non-toxic, good biocompatibility and being absorbed by cells. This paper first summarizes the research results of domestic and foreign scholars in the construction of starch microspheres as drug carriers, from which we found that the main sources of starch in starch microspheres were corn starch, potato starch, cassava starch and other types of starch. Secondly, the application of starch microspheres as drug carriers is mainly summarized. Finally, the existing problems of starch microspheres as drug carriers are pointed out in order to provide valuable guidance and reference for the controllable drug release, large-scale and clinical safety of starch microsphere drug carrier. |
| Key words：starch microspheres; drug carrier; preparation; application |
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基金項目：陜西省教育廳專(zhuān)項科研計劃項目（20JK0513），陜西國際商貿學(xué)院校級課題（SMXY202120），2021年大學(xué)生省級創(chuàng )新創(chuàng )業(yè)訓練計劃項目（S202113123051），陜西省教育廳專(zhuān)項科研計劃項目（20JK0510），陜西國際商貿學(xué)院“中藥藥物研究”創(chuàng )新團隊（SSY18TD01）資助項目。
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作者簡(jiǎn)介：問(wèn)娟娟（1987—），女，陜西渭南人，碩士，講師，研究方向：功能材料的合成及性能研究（E-mail：wjj1596249227@163.com）。
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收稿日期：2021-03-15
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