| 第 51 卷第 4 期 |  | Vol. 51 No. 4 | | 2021 年 8 月 | Aug 2021 |
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所屬欄目：分析與測試
GC內標法測定固精麥斯哈片中丁香酚含量的研究 |
| 趙 敏，姜艷玲，王莉莉，嚴 力
（西安萬(wàn)隆制藥股份有限公司，陜西 楊凌 712100） |
| 摘 要：采用氣相色譜內標法，以HP-INNOWAX毛細管柱（30 μm×530 μm×1.00 μm）為色譜柱，FID檢測器，等溫法（185 ℃），溶劑直接進(jìn)樣，建立了固精麥斯哈片中丁香酚含量的測定方法。結果表明：丁香酚在0.723 5~2.804 0 mg／mL范圍內線(xiàn)性關(guān)系良好，R2=0.999 7（n=5），平均回收率 99.36%，RSD為0.69%（n=6），重復性實(shí)驗 RSD為0.51%（n=6）。所建立的方法空白溶劑無(wú)干擾、穩定性好、準確度高、適用性強、結果可靠且易于操作，適用于測定固精麥斯哈片中丁香酚含量的測定。 |
| 關(guān)鍵詞：內標法；固精麥斯哈片；丁香酚含量；氣相色譜法 |
| 中圖分類(lèi)號：O657.7+1 文獻標識碼：A 文章編號：1009-9212（2021）04-0073-04 |
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| Determination of Eugenol in Gujing Maisiha Tablets by GC Internal Standard Method |
| ZHAO Min, JIANG Yan-ling, WANG Li-li, YAN Li
(Xi'an WanLong Pharmaceutical Co.,Ltd., Yangling 712100, China) |
| Abstract：A method for determination of eugenol content in Gujing Maisiha tablet was established using using Gas chromatography equipped with HP-INNOWAX capillary column (30 μm×530 μm×1.00 μm) and FID detector. Isothermal method (185 ℃), direct solvent injection, internal standard method were also selected in this analytical process. The results showed as followings: Eugenol had a good linear relationship in the range of 0.723 5~2.804 0 mg/mL, R2=0.999 7(n=5); the average recovery rate was 99.36%; RSD was 0.69%(n=6); RSD was 0.51% (n=6). This established method has advantages including no interference, good stability, high accuracy, strong durability, reliable results and easy operation. It is suitable for the determination of eugenol content in Gujing Maisiha tablets. |
| Key words：internal standard method; gujingmaisiha tablet; eugenol content; gas chromatography |
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作者簡(jiǎn)介：趙 敏（1989—），女，陜西楊凌人，執業(yè)藥師，主要從事藥物分析和藥品質(zhì)量管理工作。
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收稿日期： 2021-06-0
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