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第 51 卷第 5 期Vol. 51 No. 5
2021 年 10 月Oct 2021

所屬欄目:農藥及中間體

新型鄰胺基苯甲酰胺類(lèi)殺蟲(chóng)劑的創(chuàng )制研究
柳愛(ài)平1,2,任葉果1,2,李建明1,2,3,龍楚云1,2,3,蔣 彪4,劉興平1,2,歐曉明1,2,3*,劉衛東1,2,4* (1. 湖南化工研究院有限公司,國家農藥創(chuàng )制工程技術(shù)研究中心,湖南 長(cháng)沙 410014; 2. 農用化學(xué)品湖南省重點(diǎn)實(shí)驗室,長(cháng)沙410014;3. 湖南化研院檢測技術(shù)有限公司,湖南 長(cháng)沙 410014;4. 湖南海利化工股份有限公司,湖南 長(cháng)沙 410007)
摘 要:自主設計、合成了系列新型鄰胺基苯甲酰胺類(lèi)化合物,并對其進(jìn)行了殺蟲(chóng)活性、安全性、毒性、工藝、制劑、溫室和/或田間防治效果等研究,獲得了Ia、Ib和Ic等系列自主知識產(chǎn)權的高殺蟲(chóng)活性化合物。結果表明化合物Ic等對咀嚼口器害蟲(chóng)如粘蟲(chóng)和小菜蛾等的活性較鄰胺基苯甲酰胺類(lèi)殺蟲(chóng)劑氯蟲(chóng)苯甲酰胺水平相當或更勝一籌,對刺吸口器害蟲(chóng)如蚜蟲(chóng)等的活性遠優(yōu)于氯蟲(chóng)苯甲酰胺及溴氰蟲(chóng)酰胺。田間藥效試驗進(jìn)一步證實(shí),Ic等對咀嚼口器害蟲(chóng)如水稻二化螟、稻縱卷葉螟、甜菜夜蛾等的防治效果相當于或優(yōu)于氯蟲(chóng)苯甲酰胺,對刺吸口器害蟲(chóng)如蚜蟲(chóng)等的防治效果優(yōu)于溴氰蟲(chóng)酰胺。新型鄰胺基苯甲酰胺類(lèi)化合物Ic等可作為候選殺蟲(chóng)劑進(jìn)一步研究開(kāi)發(fā)。
關(guān)鍵詞:鄰胺基苯甲酰胺類(lèi)化合物;殺蟲(chóng)劑;創(chuàng )制;氯蟲(chóng)苯甲酰胺
中圖分類(lèi)號:S482.3  文獻標識碼:A  文章編號:1009-9212(2021)05-0010-04
Discovery of Novel o-Aminobenzamides as Insecticides
LIU Ai-ping1,2, REN Ye-guo1,2, LI Jian-ming1,2,3, LONG Chu-yun1,2,3, JIANG Biao4, LIU Xing-ping1,2, LUO Xian-fu1,2, WU Ming-feng1,2,3,WANG Yan1,2, LI Min1,2, HUANG Lu1,2,3, HUANG Zhi-chang1,2,3,CHEN Ming1,2, DU Sheng-hua1,2,OU Xiao-ming1,2,3*, LIU Wei-dong1,2,4* (1. National Engineering Research Center for Agrochemicals, Hunan Research Institute of Chemical Industry, Changsha 410014, China; 2. Hunan Province Key Laboratory for Agrochemicals, Changsha 410014, China; 3. HRICI Test Co.Ltd., Changsha 410014, China; 4. Hunan Haili Chemical Industry Co., Ltd., Changsha 410007, China)
Abstract:A series of new o-aminobenzamides were designed and synthesized independently. Their insecticidal activity, safety, toxicity, preparation, greenhouse and/or field efficacy were studied, a series of high insecticidal activity compounds Ia, Ib and Ic with independent intellectual property rights was obtained. The results showed that the activity of Ic against chewing mouthparts pests such as Mythimna separata and Plutella xylostellawas better than that of Chlorantraniliprole, or at the same level, the activity of Ic against the piercing-sucking mouthparts pests such as aphids was much higher than that of Chlorantraniliprole, and better than that of Cyantraniliprole. The results of field tests confirmed that the efficacy of Icagainst chewing mouth pests including Chilo suppressalis(Walker) and Cnaphalocrocis medinalis Guenee, Spodoptera exigua Hiibner was better than or equivalent to that of Chlorantraniliprole, and the efficacy of Ic against the piercing-sucking mouthparts pests such as aphids was better than or equivalent to that of Cyantraniliprole. The new o-aminobenzamide compound Ic can be used as candidate insecticides for further research and development.
Key words:o-aminobenzamide; insecticide; discovery; chlorantraniliprole.
基金項目: 國家自然科學(xué)基金項目(22177033),湖南省企業(yè)科技創(chuàng )新創(chuàng )業(yè)團隊項目(海利新材料科技創(chuàng )新創(chuàng )業(yè)團隊),湖南省重點(diǎn)研發(fā)計劃項目(2022NK2053)。
作者簡(jiǎn)介:柳愛(ài)平(1967—),女,湖南長(cháng)沙人,研究員,博士,主要從事新農藥創(chuàng )制研究與開(kāi)發(fā)(E-mail:lapliu@yahoo.com)。
聯(lián) 系 人:歐曉明,研究員,博士,主要從事農藥活性、農藥殘留化學(xué)與環(huán)境化學(xué)研究(E-mail:dexiuou@sina.com);劉衛東,博士,研究員,主要從事農藥研究與開(kāi)發(fā)(E-mail:wdliu@yahoo.com)。
收稿日期:2021-09-10
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