| 第 52 卷第 2 期 |  | Vol. 52 No. 2 | | 2022 年 4 月 | Apr 2022 |
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所屬欄目：有機合成原料
醛肟的合成及表征研究 |
| 王 瑩1, 徐小娜1, 馬紅竹2
（1. 咸陽(yáng)職業(yè)技術(shù)學(xué)院 醫藥化工學(xué)院，陜西 咸陽(yáng) 712000；2. 陜西師范大學(xué) 化學(xué)化工學(xué)院，陜西 西安 710119） |
| 摘 要：以醛2a~2o為原料，分別與鹽酸羥胺反應得到了醛肟1a~1o，其中新化合物六種（1d、1e、1f、1j、1l、1o）產(chǎn)物結構經(jīng)1H NMR和ESI-MS表征確證。并以2-硝基苯甲醛肟（1a）的合成為例，考察了影響反應的主要因素，確定醛肟的合成條件為：物料比n（鹽酸羥胺）∶n（2a）=1.2∶1.0，反應溶劑為甲醇，25 ℃反應5 min。在該條件下，2-硝基苯甲醛肟（1a）收率為90.8 %。 |
| 關(guān)鍵詞：醛肟；合成工藝；結構表征 |
| 中圖分類(lèi)號：TQ463 文獻標識碼：A 文章編號：1009-9212（2022）02-0036-03 |
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| Synthesis and Characterization of Aldoxime |
| WANG Ying1, XU Xiao-na1, MA Hong-zhu2
(1. School of Pharmaceutical & Chemical Engineering, Xianyang Vocational Technical College, Xianyang 712000, China; 2. School of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi'an 710119, China) |
| Abstract：A series of aldoxime compounds 1a~1o were prepared from the reaction of aldehydes 2a~2o with hydroxylamine hydrochloride. Among them, 1d, 1e, 1f, 1j, 1l and 1o are new compounds. The structures of the products were characterized by 1H NMR and ESI-MS. The effect of reaction conditions on the yield of product 1a was investigated as model reaction. The optimal synthesis conditions of compound 1a were as followings: the material ratio of n(hydroxylamine hydrochloride)∶n(2a) = 1.2∶1.0, the reaction mixture was stirred in methanol for 5 min at 25 ℃; the yield of 2-nitrobenzaldehyde oxime (1a) was up to 90.8 % under the optimal reaction conditions. |
| Key words：aldoxime; synthetic process; structural characterization |
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作者簡(jiǎn)介：王 瑩（1977—），女，陜西眉縣人，副教授，碩士，研究方向：有機合成化學(xué)、催化化學(xué)（E-mail:ppsurre@163.com）。
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收稿日期：2022-01-01
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