| 第 52 卷第 3 期 |  | Vol. 52 No. 3 | | 2022 年 6 月 | Jun 2022 |
|
所屬欄目：醫藥及中間體
基于對氯苯酚合成對羥基苯乙醇研究 |
| 汪愛(ài)春1，賀興宇2，3
（1. 海利貴溪新材料科技有限公司，江西 貴溪 335400；2. 湖南化工研究院有限公司 國家農藥創(chuàng )制工程技術(shù)研究中心，湖南 長(cháng)沙 410014；3. 農用化學(xué)品湖南省重點(diǎn)實(shí)驗室，湖南 長(cháng)沙 410014） |
| 摘 要：以對氯苯酚為原料，與異丁烯反應成醚保護羥基，經(jīng)格氏反應后，通入環(huán)氧乙烷得到對叔丁氧基苯乙醇，再經(jīng)氫溴酸水解得到對羥基苯乙醇。反應總收率69%（以對氯苯酚計），含量≥98.5%。解決了對羥基苯乙酸乙酯還原法成本高及苯乙醇合成法廢水量大的問(wèn)題，具有工業(yè)化應用前景。 |
| 關(guān)鍵詞：對氯苯酚；格氏化反應；酸解 |
| 中圖分類(lèi)號：TQ243.4 文獻標識碼：A 文章編號：1009-9212（2022）03-0020-03 |
|
| Synthesis of p-Hydroxyphenethyl Alcohol from p-Chlorophenol |
| WANG Ai-chun1, HE Xing-yu2,3
(1. Haili Guixi New Material Technology Co., Ltd., Guixi 335400, China；2. National Engineering Research Center for Agrochemicals, Hunan Research Institute of Chemical Industry Co.,Ltd., Changsha 410014, China; 3. Hunan Province Key Laboratory for Agrochemicals, Changsha 410014, China) |
| Abstract：p-Chlorophenol was used as the raw material, it reacted with isobutylene to form ether bonds to protect the hydroxyl group, and p-tert-butoxyphenylethanol was obtained through reactions of Grignard reaction and reaction of ethylene oxide. p-tert-Butoxyphenylethanol was then hydrolyzed using hydrobromic acid to obtain p-hydroxyphenylethanol. The total yield was 69% (as p-chlorophenol) and the purity was≥98.5%. This method solved the problems of high cost of produced p-hydroxyphenylacetic acid reduction method and large amount of wastewater from p-phenylethanol synthesis method, and has the prospect of industrial application. |
| Key words：p-chlorophenol; grignardisation reaction; acid digestion |
|
基金項目：湖南省企業(yè)科技創(chuàng )新創(chuàng )業(yè)團隊項目（湖南海利新材料科技創(chuàng )新創(chuàng )業(yè)團隊）。
|
作者簡(jiǎn)介：汪愛(ài)春（1969—），男，湖南株洲人，工程師，研究方向：農藥及中間體生產(chǎn)、技術(shù)研發(fā)（E-mail：hjlwang@163.com）。
|
收稿日期：2022-03-25
|
|