| 第 52 卷第 4 期 |  | Vol. 52 No. 4 | | 2022 年 8 月 | Aug 2022 |
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所屬欄目：功能材料
N-（4-乙氧基羰基苯基）-N-甲基-N-苯基甲脒的合成 |
| 劉 柳，孟紀文
（中昊（大連）化工研究設計院有限公司，遼寧 大連 116023） |
| 摘 要：以4-氨基苯甲酸乙酯、原甲酸三甲酯、N-甲基苯胺為原料，活性Al2O3為催化劑，一步合成了N-（4-乙氧基羰基苯基）-N'-甲基-N'-苯基甲脒�？疾炝嗽吓浔�、催化劑種類(lèi)、溫度和時(shí)間對反應的影響。優(yōu)化的工藝條件為：n（對氨基苯甲酸乙酯）∶n（原甲酸三甲酯）∶n（N-甲基苯胺）=1.00∶1.10∶1.05，活性Al2O3用量為5 g，反應溫度為60 ℃，反應時(shí)間為4 h，產(chǎn)品收率為90.5%，催化劑循環(huán)使用4次反應活性未見(jiàn)明顯下降，具有較好的穩定性。 |
| 關(guān)鍵詞：紫外線(xiàn)吸收劑；4-氨基苯甲酸乙酯；原甲酸三甲酯；N-甲基苯胺；合成 |
| 中圖分類(lèi)號：TQ246 文獻標識碼：A 文章編號：1009-9212（2022）04-0076-03 |
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| Synthesis of N-(4-Ethoxycarbonylphenyl)-N′-methyl-N′-phenyl Formamidine |
| LIU Liu, MENG Ji-wen
(China Haohua (Dalian) Research & Design Institute of Chemical Industry Co., Ltd., Dalian 116023, China) |
| Abstract：N-(4-Ethoxycarbonylphenyl)-N'-methyl-N'-phenyl formamidine was synthesized through one step from ethyl 4-aminobenzoate, trimethyl orthoformate and N-methylaniline with active Al2O3 as catalyst. The effects of raw material ratio, catalyst type, temperature and time on the reaction were investigated. The optimized process conditions were as followings: n(ethyl 4-aminobenzoate)∶n(trimethyl orthoformate)∶n(N-methylaniline) was 1.00∶1.10∶1.05; the active Al2O3 dosage was 5 g; the reaction temperature was 60 ℃; the reaction time was 4 h. Under the above conditions, a yield of 90.5% was obtained. The catalyst was recycled for 4 times with good stability. |
| Key words：ultraviolet absorber; ethyl 4-aminobenzoate; trimethyl orthoformate; N-methylaniline; synthesis |
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作者簡(jiǎn)介：劉 柳（1982—），女，遼寧錦州人，工程師，碩士，研究方向：藥物中間體及精細化學(xué)品（E-mail：postboymjw@163.com）。
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收稿日期：2022-05-05
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