| 第 53 卷第 1 期 |  | Vol. 53 No. 1 | | 2023 年 2 月 | Feb 2023 |
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所屬欄目：醫藥及中間體
吡拉西坦合成工藝的改進(jìn) |
| 庹儀敏，向莉蓉，荊一丹，肖子丹*
（長(cháng)沙理工大學(xué) 化學(xué)化工學(xué)院，湖南 長(cháng)沙 410000） |
| 摘 要：以α-吡咯烷酮為起始原料，經(jīng)與甲醇鈉反應得到吡咯烷酮鈉鹽（2），再與氯乙酸甲酯縮合得到吡咯烷酮乙酸甲酯（3），最后經(jīng)過(guò)氨解反應得吡拉西坦（1）。該制備方法三廢少、污染小、效率高、收率高，具有工業(yè)化應用前景。 |
| 關(guān)鍵詞：吡拉西坦；乙酰胺吡咯烷酮；α-吡咯烷酮；吡咯烷酮乙酸甲酯 |
| 中圖分類(lèi)號：TQ460.31 文獻標識碼：A 文章編號：1009-9212（2023）01-0039-03 |
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| Synthesis of Piracetam |
| TUO Yi-min, XIANG Li-rong, JING Yi-dan, XIAO Zi-dan*
(School of Chemistry and Chemical Engineering, Changsha University of Science & Technology, Changsha 410000, China) |
| Abstract：Using 2-pyrrolidone as starting material, pyrrolidone sodium salt (2) was prepared by substitution reaction; methyl pyrrolidone acetate (3) was obtained by the condensation reaction of 2; finally piracetam (1) was obtained by the ammonolysis reaction of 3. This preparation method has the advantages of less waste, less pollution, high efficiency and high yield, and has the prospect of industrial application. |
| Key words：Piracetam; 2-(2-oxopyrrolidino)acetamide; 2-pyrrolidinone; methyl 2-pyrrolidone-1-acetate |
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作者簡(jiǎn)介：庹儀敏（2001—），女，湖南常德人，研究方向：有機合成。
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聯(lián) 系 人：肖子丹，研究方向：精細化工中間體（E-mail：80204942@qq.com）。
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收稿日期：2022-09-08
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