| 第 53 卷第 2 期 |  | Vol. 53 No. 2 | | 2023 年 4 月 | Apr 2023 |
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所屬欄目：功能材料
己基咔唑衍生物電化學(xué)傳感器制備及Mn2+檢測應用 |
| 金美玉1，吳 比1，孫艷青1，劉欣宇1，周淑晶1，2，欒 芳1，2*，馮艷茹1，2*
（1. 佳木斯大學(xué) 藥學(xué)院，黑龍江 佳木斯 154007；2. 佳木斯大學(xué) 黑龍江省新藥開(kāi)發(fā)與藥理毒理評價(jià)重點(diǎn)實(shí)驗室，黑龍江 佳木斯 154007） |
| 摘 要：采用vilsmeier甲�；土u醛縮合法合成N-己基咔唑衍生物，通過(guò)紅外光譜、質(zhì)譜和核磁共振氫譜對化合物結構進(jìn)行表征確證；采用滴涂法制備N(xiāo)-己基咔唑/rGO/GCE復合電極，通過(guò)循環(huán)伏安曲線(xiàn)測試和阻抗測試進(jìn)行表征；采用循環(huán)伏安檢測Mn2+。結果表明HD4/rGO/GCE對Mn2+電化學(xué)響應較好。在掃描速度50 mV/s、pH=4的優(yōu)化條件下，Mn2+濃度在2~200 μmol/L線(xiàn)性關(guān)系良好，最低檢測限為0.298 μmol/L（S/N=3）。選取最優(yōu)修飾電極用于Mn2+標準品測定，加標回收率為98.0%~101.0%。結果表明HD4/rGO/GCE具有良好的穩定性、重復性和抗干擾性。 |
| 關(guān)鍵詞：N-己基咔唑衍生物；復合電極；循環(huán)伏安；Mn2+ |
| 中圖分類(lèi)號：O657.1 文獻標識碼：A 文章編號：1009-9212（2023）02-0051-07 |
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| Preparation of N-hexyl Carbazole Derivative Electrochemical Sensor and Applications for Mn2+ Detection |
| JIN Mei-yu1, WU Bi1, SUN Yan-qing1, LIU Xin-yu1, ZHOU Shu-jing1,2, LUAN Fang1,2*, FENG Yan-ru1,2*
(1. Pharmacy College, University of Jiamusi, Jiamusi 154007, China; 2. Heilongjiang Provincial Key Laboratory of New Drug Development and Pharmacotoxicological Evaluation, University of Jiamusi, Jiamusi 154007, China) |
| Abstract：N-hexyl carbazole derivatives were synthesized through vilsmeier formylation and hydroxyl acetylation. The structures of the compounds were characterized by infrared spectroscopy and mass spectrometry. N-hexyl carbazole/rGO/GCE composite electrode was prepared by drip coating method and characterized by cyclic voltammetry curve and impedance test. Cyclic voltammetry was used to detect Mn2+. The results showed that HD4/rGO/GCE had the best electrochemical response to Mn2+.Under the best experimental conditions of the optimal scanning speed was 50 mV/s and the pH was 4, Mn2+ concentration showed a good linear relationship between 2~200 μmol/L and the lowest detection limit was 0.298 μmol/L (S/N=3). The optimal modified electrode was selected for the determination of Mn2+ standard, and the recoveries were 98.0%~101.0%. The results showed that HD4/rGO/GCE had good stability, repeatability and anti-interference. |
| Key words：N-hexyl carbazole derivate; composite electrode; cyclic voltammetry; Mn2+ |
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基金項目：黑龍江省教育廳基礎科研業(yè)務(wù)費項目（2019-KYYWF-1343），佳木斯大學(xué)博士科研啟動(dòng)基金項目（JMSUBZ2019-12），黑龍江省新藥開(kāi)發(fā)與藥理毒理評價(jià)重點(diǎn)實(shí)驗室開(kāi)放項目（kfkt2022-04）。
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作者簡(jiǎn)介：金美玉（1998—），女，黑龍江巴彥人，碩士，研究方向：分析化學(xué)（E-mail：2696426003@qq.com）。
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聯(lián) 系 人：欒 芳，副教授，研究方向：有機光電材料的制備及應用（E-mail：fangfang628628@126.com）；馮艷茹，副教授，研究方向：有機小分子設計合成及其應用（E-mail：nancy_fyr@163.com）。
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收稿日期：2023-03-30
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