| 第 33 卷第 3 期 |  | Vol. 33 No. 3 | | 2003 年 6 月 | Jun 2003 |
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所屬欄目：專(zhuān)論與綜述
2-氯-5-甲基吡啶的合成方法 |
| 趙寶祥; 王大威; 左華(山東大學(xué)化學(xué)與化工學(xué)院有機化學(xué)研究所; 山東濟南; 250100) |
| 摘 要：介紹了2-氯-5-甲基吡啶的四種類(lèi)型的合成方法,包括以3-甲基吡啶-N-氧化物為原料的氯化法、2-氨基-5-甲基吡啶氯化法、環(huán)合氯化法、3-甲基吡啶直接氯化法等 |
| 關(guān)鍵詞：2-氯-5-甲基吡啶; 中間體; 合成 |
| 中圖分類(lèi)號：TQ253.2 文獻標識碼：A 文章編號：1009-9212(2003)03-0008-03 |
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| Preparation of 2-Chloro-5-methylpyridine |
| ZHAO Bao xiang etc.（Institute of Organic Chemistry; School of Chemistry & Chemical Engineering; Shandong University; Jinan; 250100; China） |
| Abstract：The preparation methods of 2 chloro 5 methylpyridint were reviewed. Those include(1) the preparation from 3 methylpyridine N oxide by different kinds chlorinating reagents such as phosphoryl chloride, N,N diethyl dichlorophosphoramide, dichloromethylene dimethylimmonium chloride, o phthaloyl chloride, trifluoromethyl sulphonyl chloride and phosgene; (2) the preparation from 2 aminopyridine by the reaction with methyl nitrite in hydrogen chloride saturated solution; (3)the preparation from acete... |
| Key words：chloro 5 methylpyridine; intermediate |
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收稿日期：2003-02-13
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