| 第 33 卷第 4 期 |  | Vol. 33 No. 4 | | 2003 年 8 月 | Aug 2003 |
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所屬欄目：其它
苯氧菌酯的合成研究 |
| 劉衛東; 徐道莊; 杜升華; 吳光群(湖南化工研究院; 湖南長(cháng)沙) |
| 摘 要：以苯酞和鄰甲酚為起始原料 ,生成物經(jīng)酰氯化、酰氰化、水解反應得苯基草酸甲酯衍生物 ,再與甲氧基氨鹽酸反應得Z/E構型混合物。該混合物經(jīng)轉位反應得苯氧菌酯。反應總收率為 57.2% (以苯酞計 ) ,產(chǎn)品純度為 95 %。該工藝流程簡(jiǎn)單 ,易于工業(yè)化生產(chǎn) |
| 關(guān)鍵詞：苯氧菌酯; 鄰甲酚; 苯酞; 合成 |
| 中圖分類(lèi)號：TQ245.2+4 文獻標識碼：A 文章編號：1009-9212(2003)04-0010-02 |
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| The Synthesis Study on Kresoxim-methyl |
| LIU Wei dong etc.（Hunan Research Institute of Chemical Industry; Changsha; 410007; China） |
| Abstract：Kresoxim methyl was prepared by reacting the intermediate, methyl 2 (2 methylphenoxymethyl) phenylglyoxylate, with O-methylhydroxylamine hydrochloride. The resulting E/Z isomer mixture was treated with hydrochloride for substantial rearrangement of the Z to the E isomer. The intermediate was synthesized by using O cresol, phthalide, thionyl chloride, and sodium cyanide as raw materials. The total yield of the five steps reaches 57.2% (according to phthalide), and the process is convinient and suitable f... |
| Key words：Kresoxim-methyl; O cresol; phthalide; synthesis |
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收稿日期：2003-05-08
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