| 第 33 卷第 6 期 |  | Vol. 33 No. 6 | | 2003 年 12 月 | Dec 2003 |
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所屬欄目：其它
黃連素β-環(huán)糊精包合物的制備及抑菌試驗研究 |
| 李志平; 歐陽(yáng)玉祝; 章愛(ài)華; 吳醞(吉首大學(xué)化學(xué)化工學(xué)院; 湖南吉首) |
| 摘 要：用正交實(shí)驗法制備了黃連素β 環(huán)糊精包合物,考察了環(huán)糊精用量、反應時(shí)間和黃連素用量等因素對包合物的影響。用紫外分光光度法測定了包合物的溶解度和包結比,并對包合物與黃連素的抑菌能力作了比較。實(shí)驗結果表明:黃連素用量為0.030g,β 環(huán)糊精2.0g,包合時(shí)間90min,包合物收率可達68%以上。包合物的溶解度為4.826g/100ml水,包結比為1:2,抑菌試驗表明:包合物的抑菌能力比黃連素稍有增強。 |
| 關(guān)鍵詞：黃連素; 包合物; β-環(huán)糊精 |
| 中圖分類(lèi)號：R975+.3 文獻標識碼：A 文章編號：1009-9212(2003)06-0046-03 |
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| A Study on Preparation of Inclusion Complexes of Berberine with β-Cyclodextrin and Bacterium Test |
| LI Zhi ping; etc （College of Chemistry and Chemical engineering; Jishou University; Jishou Hunan 416000; China） |
| Abstract：The inclusion complexes of berberine with β Cyclodextrin were made by orthonormal test. The factors, such as the amount of β Cyclodextrin and berberine, and reacting times on inclusion reaction, were investigated. Solubility and molar ratio of β Cyclodextrin inclusion complexes was measured by U vis spectrophoto metry, and the ability of bacteriostatic was compared. The results show that when the amount of berberine and β Cyclodextrin is 0.03g and 2.0g, and the reacting time 90min, the ratio of inclus... |
| Key words：berberine; inclusion complexes; β-Cyclodextrin |
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基金項目：湖南省教育廳資助課題(01C300)
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收稿日期：2003-06-30
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