| 第 33 卷第 6 期 |  | Vol. 33 No. 6 | | 2003 年 12 月 | Dec 2003 |
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所屬欄目：其它
依帕司他中間體α-甲基肉桂醛的合成 |
| 左華; 趙寶祥; 王大威(山東大學(xué)化學(xué)與化工學(xué)院有機化學(xué)研究所; 山東濟南) |
| 摘 要：研究了由苯甲醛、丁醛合成α 甲基肉桂醛的工藝,考察了催化劑用量、原料摩爾比、反應時(shí)間對合成α 甲基肉桂醛收率的影響。其優(yōu)化條件是:以乙醇作溶劑,四丁基溴化銨為催化劑,n(苯甲醛)∶n(丙醛)∶n(催化劑)1.4∶1∶0.015,室溫反應6h,收率達84.6%,且過(guò)量的苯甲醛能回收。 |
| 關(guān)鍵詞：相轉移催化; 苯甲醛; 丙醛; α-甲基肉桂醛; 合成 |
| 中圖分類(lèi)號：TQ224.13 文獻標識碼：A 文章編號：1009-9212(2003)06-0036-02 |
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| The Synthesis of α-Methylcinnamaldehyde as Intermediate of Epalrestat |
| ZUO Hua; etc（Institute of Organic Chemistry; School of Chemistry and Chemical Engineering Shandong University; Jinan Shandong 250100; China） |
| Abstract：The influence factors on the yield of α-methylcinnamaldehyde, such as kind of catalysts, dosage of catalyst, molar ratio of benzaldehyde to n propylaldehyde, and reaction time were investigated. The optimum preparation conditions are as follows∶n(benzaldehyde)∶n(n propylaldehyde)∶n(catalyst)=1.4∶1∶0.015, 6 h of reaction time with ethanol as solvent, tetrabutylammonium bromide as catalyst, and reacting at room temperature. The yield of α methylcinnamaldehyde reaches 84.6%, and surplus benzaldehyde could b... |
| Key words：phase transfer catalysis; α-methylcinnamaldehyde; synthesis |
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收稿日期：2003-06-16
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