| 第 33 卷第 6 期 |  | Vol. 33 No. 6 | | 2003 年 12 月 | Dec 2003 |
|
所屬欄目：其它
4-溴甲基-2(H)-喹啉酮的合成研究 |
| 楊藝虹; 張珩; 李培成(武漢化工學(xué)院; 武漢化工研究所; 湖北武漢) |
| 摘 要：以苯胺為原料,經(jīng)雙乙烯酮在甲苯中�；靡阴Ｒ阴１桨�;在氯仿中溴化得溴乙酰乙酰苯胺;然后在濃硫酸中環(huán)合制得4 溴甲基 2(H) 喹啉酮。結果表明:合成總收率為62.5%,含量達98.6%。該法原料易得,操作簡(jiǎn)便,總收率高。 |
| 關(guān)鍵詞：2-（H）-喹啉酮; 溴化反應; 環(huán)合反應; 合成; 瑞巴匹特 |
| 中圖分類(lèi)號：TQ253.23 文獻標識碼：A 文章編號：1009-9212(2003)06-0029-02 |
|
| The Synthesis of 4-Bromothyl-2(H)-Quinolinone |
| YANG Yi hong; etc （Wuhan Institute of Chemical Technology; Wuhan Hubei 430073; China） |
| Abstract：4-Bromoethyl 2(H) quinolinone was synthesized by the acylation of aniline with biketene in toluene, the bromination in chloroform, and the cyclization in sulfuric acid. The result shows that the overall yield is 60.36% and content up to 98.6%. The raw material can be gotten easily using the method. The operating process is simple, and the yield is high. |
| Key words：2（H）-quinolinone; bromination; cyclization; synthesis |
|
收稿日期：2003-09-15
|
| 閱讀全文 |
|