| 第 34 卷第 1 期 |  | Vol. 34 No. 1 | | 2004 年 2 月 | Feb 2004 |
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所屬欄目：其它
5-取代-1H-1,2,4-三氮唑-3-羧酸的合成及結構表征 |
| 李德江; 孫碧海; 李斌(湖北省丹江口市鄖陽(yáng)師范專(zhuān)科學(xué)�；瘜W(xué)系; 武漢化工學(xué)院制藥工程系; 湖北丹江口市; 湖北武漢) |
| 摘 要：以5 氯基 1H 1,2,4 三氮唑 3 羧酸乙酯為原料,經(jīng)Sandmeyer反應合成了5 取代 1H 1,2,4 三氮唑 3 羧酸乙酯,其中取代基為氯、溴、碘、氰基等。并通過(guò)UV,IR,1HNMR和元素分析對所有產(chǎn)物的結構進(jìn)行了表征。 |
| 關(guān)鍵詞：5-氨基-1H-1; 2; 4-三氮唑-3-羧酸乙酯; Sandmeyer反應; 合成; 表征 |
| 中圖分類(lèi)號：TQ252.6 文獻標識碼：A 文章編號：1009-9212(2004)01-0035-03 |
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| The Synthesis of 5-Substituting group-1H-1,2,4-Triazole-3-Carboxylic Acid Ethyl Ester |
| LI De-jiang~1; SUN Bi-hai~2; LI Bin~2 （1.Department of Chemistry; Yunyang Teachers College; Danjiangkou 442700; China; 2.Department of Pharmaceutical Technology; Wuhan Institute of Chemical Technology; Wuhan 430073; China） |
| Abstract：1H-1,2,4-triazole derivatives,owing to their extensive uses in pharmaceutical synthesis,in an effort to search for more useful reaction intermediates containing 1H-1,2,4-triazole, four new 5-substituted-1H-1,2,4-triazoles were synthesized from 5-amino-1H-1,2,4-triazole-3-carboxylic acid ethyl ester by Sandmeyer reaction. Their structures were confirmed by elementl analysis, IR, UV and ~1 HNM. |
| Key words：5-amino-1H-1; 2; 4-triazole-3-carboxylic acid ethyl ester; Sandmeyer reactipn; synthesis; characterization |
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收稿日期：2003-08-22
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