| 第 34 卷第 1 期 |  | Vol. 34 No. 1 | | 2004 年 2 月 | Feb 2004 |
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所屬欄目：其它
(S)-4-氯-3-羥基丁酸乙酯的不對稱(chēng)合成 |
| 張敏; 魏俊發(fā)(陜西師范大學(xué)化學(xué)與材料科學(xué)學(xué)院; 西安710062西安近代化學(xué)研究所西安) |
| 摘 要：報道了用4 氯 乙酰乙酸乙酯為原料,以面包酵母為還原劑,選擇性合成(s) 4 氯 3 羥基丁酸乙酯。分別考察了能源供體、蔗糖濃度、反應溫度、底物加量和壓榨酵母用量等因素對產(chǎn)物收率和對映體過(guò)量值的影響。結果表明,4 氯 乙酰乙酸乙酯不對稱(chēng)生物還原反應的適宜條件為:能源供體40.0g/L蔗糖,反應溫度36.5℃,壓榨酵母50.0g/L,底物加量12.0g/L,pH為7.0。反應收率可達60.5%,ee收率為98.5%。 |
| 關(guān)鍵詞：面包酵母; 4-氯-3-羥丁酸乙酯; 手性合成 |
| 中圖分類(lèi)號：TQ225.24+ 文獻標識碼：A 文章編號：1009-9212(2004)01-0033-02 |
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| The Asymmetry Synthsis of 4-Cloro-3-Hydroxybutyric Acid Ethyl Ester With Baker's Yeast |
| Zhang Min~（1; 2）; Wei Jun-fa~1 （1.School of Chemistry and Material Science; Shanxi Noraml University; Xi'an; 710062; China; 2.XI'AN Morden Chemistry Research Insitute Xi'an; 710065; China） |
| Abstract：Optically active ethyl (s)-4-chloro-3-hydroxybutyrat,a useful chiral synthon, was prepared by stereoselective bioreduction of ehtyl 4-cloro-acetoacetate with baker's yeast. The factors influencing the synthesis were discussed such as reaction temperature, pH's degree, energy source, and so on. At the optimum reaction conditions were determined as follows: energy source was 40.0g/L of sucrose, reation temperature 36.5?℃, pH 7.0. The yield and enantiiomeric excess(ee) of the product are 60.5% and 98.5%, respe... |
| Key words：biocatalysis baker's yeast; asmmetric reduction; ethyl 4-cloro-acetoacetate; ethyl（s）-4-cloro-3-hydroxybutyrat |
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基金項目：國家自然科學(xué)基金資助項目(20172036)。
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收稿日期：2003-09-03
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