| 第 34 卷第 3 期 |  | Vol. 34 No. 3 | | 2004 年 6 月 | Jun 2004 |
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所屬欄目：其它
強酸性離子交換膜催化合成5-乙氧羰基-4-(4-甲氧苯基)-6-甲基-3,4-二氫嘧啶-2(1H)-酮 |
| 李治; 施婷婷; 倪淑晶(華東理工大學(xué)化學(xué)與制藥學(xué)院) |
| 摘 要：在HF-101強酸性離子交換膜的存在下,由茴香醛、乙酰乙酸乙酯與脲一步合成了5 乙氧羰基 4 (4 甲氧苯基) 6 甲基 3,4 二氫嘧啶 2(1H) 酮。當茴香醛、乙酰乙酸乙酯與脲的摩爾比為1:2:5,乙醇作溶劑,4g離子交換膜,回流2h,產(chǎn)物收率達95 2%。同時(shí)研究了離子交換膜作為催化劑的重復使用情況。 |
| 關(guān)鍵詞：強酸型離子交換膜; 催化; 藥物中間體; 5-乙氧羰基-4-（4-甲氧苯基）-6-甲基3; 4-二氫嘧啶-2-（1H）-酮 |
| 中圖分類(lèi)號：TQ254.1 文獻標識碼：A 文章編號：1009-9212(2004)03-0020-02 |
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| Synthesis of 5-ethoxycarbonyl-4-(4-methoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one by Catalysis of Strong Acidic Ion-exchange Membrane |
| LI Zhi; SHI Ting-ting; NI Shu-jing （East China University of Science and TEchnology; Shanghai 200237; China） |
| Abstract：5-ethoxycarbonyl-4-(4-methoxyphenyl)-6-methyl-3,4-dihydro-pyrimidin-2(1H)-one was synthesized from anisaldehyde, ethyl acetoactate, and urea in presence of HF-101 strong acidic ion-exchange membrane. The yield of the 3,4-dihydropyrimidin-2(1H)-one was up to 95.2% under the optimum cordition: moler ratio of anisaldehyde, ethyl acetoactate and urea 1:2:5, ion-exchange membrane 4 g, ethyl alcohol as solvent and refluxing for 2 h. The reusability of the catalyst was studied. |
| Key words：HF-101 strong acidic ion-exchang membrane; catalysis; pharmaceutical intermediate; synthesis; 5-ethoxycarbonyl-4-（4-methoxyphenyl）-6-methyl-3; 4-dihydropyrimidin-2（1H）-one |
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收稿日期：2004-03-11
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