| 第 34 卷第 3 期 |  | Vol. 34 No. 3 | | 2004 年 6 月 | Jun 2004 |
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所屬欄目：其它
固載型手性海因催化合成(S)-α-氰基-3-苯氧基苯甲醇 |
| 顧紅; 翟志才(鹽城工學(xué)院化學(xué)工程系; 江蘇鹽城) |
| 摘 要：以混合溶劑法由D 氨基酸和異氰酸酯制備一系列3,5 二取代手性海因,用大孔吸附樹(shù)脂作載體,制成固載型手性催化劑,并考察了不同結構手性海因化合物在3 苯氧基苯甲醛氰醇化反應中的催化活性。結果表明,所采用的手性海因制備方法簡(jiǎn)便,在(S) α 氰基 3 苯氧基苯甲醇的不對稱(chēng)合成中表現了較好的對映選擇性,其氰醇ee值約為20%～35.5%。 |
| 關(guān)鍵詞：手性海因; 大孔吸附樹(shù)脂; α-氰基-3-苯氧基苯甲醇; 不對稱(chēng)合成; 光學(xué)活性 |
| 中圖分類(lèi)號：TQ243.4 文獻標識碼：A 文章編號：1009-9212(2004)03-0016-04 |
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| Preparation of α-Cyano-3-phenoxybenzyl Alcohol Catalyzed by Supported Chiral Hydantoin |
| GU Hong; ZHAI Zhi-cai （Department of Chemical Engineering of Yancheng Institute of Technology; Yancheng 224003; China） |
| Abstract：A series of 3,5-disubstituted chiral hydantoins were prepared from D-amino acid and phenyl isocyanate in mixed solvent, and the catalyst was then supported on macroporous adsorption resins. The catalytic activitiy of the chiral hydantoins with different structures was investigated in the asymmetric cyanohydrination of 3-phenoxy benzaldehyde. The result showed that the improved process for preparation of chiral hydantoins is easy in operation, and the supported chiral hydantoins all exhibited sound enantiose... |
| Key words：Chiral hydantoin; macroporous adsorptive resin; α-cyano-3-phenoxybenzyl alcohol; asymmetric synthesis; optical activity |
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收稿日期：2004-03-12
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