| 第 34 卷第 4 期 |  | Vol. 34 No. 4 | | 2004 年 8 月 | Aug 2004 |
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所屬欄目：其它
法昔洛韋原料的合成工藝研究 |
| 金義翠(南京工業(yè)大學(xué)制藥與生命科學(xué)學(xué)院; 江蘇南京) |
| 摘 要：對法昔洛韋的生產(chǎn)工藝中的反應時(shí)間、溫度、試劑的選擇等進(jìn)行探索、改進(jìn),使總收率從21%提高到30%,純度達到99%以上,該工藝降低了生產(chǎn)成本,更適合工業(yè)化生產(chǎn)。 |
| 關(guān)鍵詞：法昔洛韋; 藥物; 工藝改進(jìn) |
| 中圖分類(lèi)號：TQ0626.32 文獻標識碼：A 文章編號：1009-9212(2004)04-0039-03 |
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| A Novel Synthesis Technology of Famciclovir |
| JIN Yi-cui （Nanjing University of Technology; Nanjing 210019; China） |
| Abstract：Famciclovir is a kind of new antiviral drug, which has a wide market prospect. In view of the present problems in the synthesis of Famciclovir and a large amount of literature, the optimum technology including reaction time, temperature , reagent, etc was studied. The overall yield was raised from less than 21% to about 30%, and the purity reaches above 99% in improved method. The process has the advantage of lower cost, so it can meet the requirements of industrial production. |
| Key words：amciclovir; drug; improved synthesis |
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收稿日期：2004-05-20
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