| 第 34 卷第 4 期 |  | Vol. 34 No. 4 | | 2004 年 8 月 | Aug 2004 |
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所屬欄目：專(zhuān)論與綜述
丙二酸二乙酯的合成進(jìn)展 |
| 宋偉紅; 姜玄珍(中石化上海石油化工研究院; 浙江大學(xué)化學(xué)系; 浙江杭州) |
| 摘 要：丙二酸二乙酯是重要的有機合成中間體,廣泛應用于醫藥、染料和香料等工業(yè)。傳統的氰化鈉法由于流程長(cháng),收率低,污染環(huán)境而亟待改進(jìn)。近年來(lái)研究比較活躍的催化羰基化法,是典型的原子經(jīng)濟型反應,步驟少,收率高,綠色環(huán)保,與其它合成方法比較具有較大的優(yōu)勢,可望替代傳統方法。 |
| 關(guān)鍵詞：丙二酸二乙酯; 羰基化; 相轉移催化法 |
| 中圖分類(lèi)號：O623.624.2 文獻標識碼：A 文章編號：1009-9212(2004)04-0015-03 |
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| Recent Progress in the Synthesis of Diethyl Malonate |
| SONG Wei-hong~1; JIANG Xuan-zhen~2 （1.Shanghai Research Insititute of Petro-chemical Technology; Shanghai 201208; China; 2.Department of Chemistry; Zhejiang University; Hangzhou 310027; China） |
| Abstract：Diethyl malonate is an important organic synthetic intermediate which is widely used in the production of pharmaceutical, colorants and spicery. The traditional method (NaCN route) should be improved for its plurality of steps, low yields and pollution problem. The novel carbonylation method in which phase transfer catalysis and cobalt carbonyl complexes were used exhibited higher yield and lower cost as well as environmental benignancy. Therefore carbonylation route will be a promising method in industrial... |
| Key words：diethyl malonate; carbonylation; phase transfer catalysis |
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收稿日期：2004-03-26
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