| 第 35 卷第 1 期 |  | Vol. 35 No. 1 | | 2005 年 2 月 | Feb 2005 |
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所屬欄目：其它
6-羥基-2-乙酰萘的制備 |
| 張廣; 李加榮; 李文婷(北京理工大學(xué)化工與環(huán)境學(xué)院新醫藥研發(fā)中心) |
| 摘 要：采用6 甲氧基 2 乙酰萘與濃鹽酸在縛酸劑三乙胺存在的條件下進(jìn)行水解反應制得6 羥基 2 乙酰萘。同時(shí)通過(guò)正交設計研究了反應的優(yōu)化條件,即 6 甲氧基 2 乙酰萘、濃鹽酸、三乙胺與二氯甲烷的比例為:1 g∶90 ml∶0.75 ml∶2.5 ml,反應收率為 79%。反應監控為T(mén)LC(展開(kāi)劑為:正庚烷、二氯甲烷和丙酮=3∶6∶2.5,v/v)。鹽酸的用量大幅度降低,產(chǎn)品成本降低36%。 |
| 關(guān)鍵詞：老年癡呆; 探針技術(shù); 6-羥基-2-乙酰萘; 水解 |
| 中圖分類(lèi)號：TQ241.5 文獻標識碼：A 文章編號：1009-9212(2005)01-0055-03 |
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| The preparation of 6-hydroxy-2-acetonaphthene |
| ZHANG Guang; LI Jia-rong; LI Wen-ting（Beijing Institute of Technology; College of Chemical Engineering & Environment; Center of New Drugs Discovery; Beijing 100081; China） |
| Abstract：hydroxy-2-acetonaphthene was obtained by the hydrolysis of 6-methoxy- 2-acetonaphthene in the presence of HCl (36%) and triethylamine as a catalyst. The optimum conditions were studied by orthogonal design. The ratio of 6-methoxy-2-acetonaphthene/ conc.HCl/Et_(3)N/CH_(2)Cl_(2) was 1∶90∶0.75∶2.5(g∶v∶v∶v), and the yield was 79%. The reaction was monitored by TLC, and the developed solution.was n-heptane:CH_(2)Cl_(2):acetone (3∶6∶2.5, v/v). The consumption of HCl was reduced greatly and the cost was dropped by... |
| Key words：Alzheimer’s disease; probe technique; 6-hydroxy-2-acetonaphthene; hydrolysis |
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基金項目：北京理工大學(xué)基礎資金資助(No 000Y05)。
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收稿日期：2004-05-28
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