| 第 35 卷第 1 期 |  | Vol. 35 No. 1 | | 2005 年 2 月 | Feb 2005 |
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所屬欄目：其它
扁桃酸的光學(xué)拆分 |
| 臧健; 王志軍; 吳怡祖(南京工業(yè)大學(xué); 江蘇南京) |
| 摘 要：描述了用D-(-)-苯甘氨酸丁酯及其鹽酸鹽為拆分劑,在水或醇的反應體系中,與扁桃酸反應,制備R-(-)-扁桃酸和 S-(+)-扁桃酸的過(guò)程;其中 R-(-)-扁桃酸有 98.9%的收率和32 %的光學(xué)純度;而S-(+)-扁桃酸有90.1%的收率和 66.73%的光學(xué)純度。另外也描述了苯甘氨酸丁酯及其鹽酸鹽的一般合成方法。 |
| 關(guān)鍵詞：拆分; 扁桃酸; 光學(xué)活性; 苯甘氨酸丁酯; 苯甘氨酸丁酯鹽酸鹽 |
| 中圖分類(lèi)號：TQ245.4 文獻標識碼：A 文章編號：1009-9212(2005)01-0050-03 |
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| The Optical Resolution of Mandelic Acid |
| ZANG Jian; WANG Zhi-jun; WU Yi-zu（Nanjing University of Technology; Jiangsu 210009; China） |
| Abstract：A process was disclosed for resolving mandelic acid using optically active phenylglycine butyl ester or its hydrochloride. The yield and optical purity of S-(+)-mandelic are 90.1% and 66.73% for At the same time, The yield and optical purity R-(-)-mandelic acid are 98.9% and 32% respectively. Additionally, a general synthetic method of phenylglycine butyl ester and its hydrochloride was disclosed. |
| Key words：resolution; mandelic acid; optically active; phenylglycine ester; phenylglycine ester hydrochloride |
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收稿日期：2004-10-26
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