| 第 35 卷第 1 期 |  | Vol. 35 No. 1 | | 2005 年 2 月 | Feb 2005 |
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所屬欄目：其它
對二甲苯硝化還原法合成2,5-二甲酚 |
| 劉登科; 黃長(cháng)江; 閆芳芳; 王平保(天津藥物研究院) |
| 摘 要：對二甲苯與混酸(硝酸/濃硫酸)經(jīng)硝化反應制得 2,5-二甲基硝基苯,再經(jīng)鈀炭-甲酸銨催化氫轉移還原反應、重氮化/水解反應,最終制得 2,5-二甲基苯酚。三步反應在后處理時(shí)均采用水蒸汽蒸餾。優(yōu)化了反應條件,簡(jiǎn)化了操作,總收率達47%。 |
| 關(guān)鍵詞：2; 5-二甲基苯酚; 5-二甲基苯胺; 催化氫轉移還原法; 水蒸汽蒸餾; 硝化反應 |
| 中圖分類(lèi)號：O625.4 文獻標識碼：A 文章編號：1009-9212(2005)01-0038-02 |
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| Synthesis of 2,5-dimethylpheool |
| LIU Deng-ke; HUANG Chang-jiang; YAN Fang-fang; WANG Ping-bao（Tianjin Institute of Pharmaceutical Reserch; Tianjin 300193; China） |
| Abstract：2,5-dimethylphenol was prepared starting from p-xylene through Nitration with HNO_3/H_2SO_4, reduction with Pd/C-HCOONH_4 and diazotization/ hydrolysis. The steam distillation was applied in three steps. The overall yield is 47%. |
| Key words：2; 5-dimethylphenol; 5-dimethylaniline; catalytic transfer hydrogenation; steam distillation; nitration |
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收稿日期：2004-09-21
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