| 第 35 卷第 2 期 |  | Vol. 35 No. 2 | | 2005 年 4 月 | Apr 2005 |
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所屬欄目：其它
除草劑炔草酯的合成研究 |
| 陳強; 廖文文; 劉智凌(江蘇寶靈化工股份有限公司; 湖南師范大學(xué)化學(xué)化工學(xué)院; 湖南化工研究院; 江蘇南通; 湖南長(cháng)沙) |
| 摘 要：以5氯2,3二氟吡啶與(R)2(對羥基苯氧基)丙酸為原料,以二甲基甲酰胺(DMF)為溶劑,K2CO3為縛酸劑,在70℃下醚化反應4h,然后再加入氯丙炔,以甲苯為溶劑,反應溫度70～75℃,降溫后過(guò)濾除鹽,DMF洗滌,脫溶,再用乙醇/水結晶,干燥得產(chǎn)品,含量98%,以(R)2(對羥基苯氧基)丙酸計總收率86%。 |
| 關(guān)鍵詞：炔草酯; 頂尖; 除草劑; 5-氯-2; 3-二氟吡啶; R-2-（對羥基苯氧基）丙酸 |
| 中圖分類(lèi)號：TQ457.2 文獻標識碼：A 文章編號：1009-9212(2005)02-0035-02 |
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| Synthesis of the herbcidal chodinafop-propargyl |
| CHEN Jing~（1）; LIAO Wen-wen~（2）（1.Jiangsu Baoling Chemical Co Ltd; Nantong 226006; China; 2.Hunan Normal University; Changsha 410082; 3.Hunan Research Institute of Chemical Industry; Changsha 410007; China） |
| Abstract：Chodinafop-propargyl was synthesized from R-2-(p-hydroxyphenoxy)-propionic acid and 5-chloro 2,3-difluoropyridine and propargyl chloride. At first R-2-(p-hydroxyphenoxy)-propionic acid was converted into the corresonding potassium with potassium carbonate powder and tetrabutyl ammonium bromide in DMF at 70℃,then 5-chloro–2,3-difluoropyridine was added over course of 30 min ,after 4 hours, propargyl chloride was added over 2 hours to form the (R)(+)-2-[4-(5-chloro-3-fluoropyridin-2-yloxy)-phenoxy]-propionic ... |
| Key words：chodinafop-propargyl; Topic; herbcidal; l; 5-chloro–2; 3-difluoropyridine; R-2-（p-hydroxyphenoxy）-propionic acid |
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收稿日期：2004-02-26
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