| 第 35 卷第 2 期 |  | Vol. 35 No. 2 | | 2005 年 4 月 | Apr 2005 |
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所屬欄目：其它
1-乙酰氨基-3,5-二甲基金剛烷的水解反應研究 |
| 任會(huì )學(xué); 林吉茂; 薛云; 李紅梅; 馮永斌(山東大學(xué)化學(xué)與化工學(xué)院; 山東濟南) |
| 摘 要：通過(guò)對酰胺水解反應的機理的分析,針對1乙酰氨基3,5二甲基金剛烷空間位阻大、取代基為推電子基團的特點(diǎn),對其水解反應對收率的影響進(jìn)行了研究。結果表明:此化合物的水解適宜在堿性條件下進(jìn)行,且在n(反應物)∶n(苛性鈉)=1∶5,溶劑為水:乙二醇=1∶10,150℃下反應12h,得到最終產(chǎn)品鹽酸美金剛的收率為92.5%,純度為99.5% |
| 關(guān)鍵詞：1-乙酰氨基-3; 5-二甲基金剛烷; 水解反應; 鹽酸美金剛 |
| 中圖分類(lèi)號：O624.1 文獻標識碼：A 文章編號：1009-9212(2005)02-0029-03 |
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| Study on the Hydrolytic Reaction of the 1-Acetamido-3,5-Dimethyladamantane |
| REN Hui-xue; LIN Ji-mao; XUE Yun; LI Hong-mei; FENG Yong-bin（School of Chemical and Engineering of Shandong University; Jinan 250100; China） |
| Abstract：Through analyzing the mechanism of the hydrolysis of amides,the effects of the hydrolysis on yields of the product were studied.According to the special character of 1-acetamido-3,5-dimethyladamantane,which has big special resistance and substituents pushing electron group.The optimum condition is as follows:hydrolized in alkaline condition,n(reactant)∶n(alkali)=1∶5,the solvent is the mixture of water and ethylene glycol 1∶10(v/v),and the reaction is kept at 150 ℃ for 12 h.The yield of product is 92.5%,the ... |
| Key words：1-acetamido-3; 5-dimethyladamantane; hydrolysis; memantine hydrochloride |
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收稿日期：2004-12-15
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